OK: Found an XML parser.
OK: Support for GZIP encoding.
OK: Support for character munging.

Notice: MagpieRSS [debug] Returning STALE object for http://theghana-italynews.com/feed in /www/eteamsys/com/eteamsys/local/htdocs/lib/magpie/rss_fetch.inc on line 243

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Channel: Bofads

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      ["title"]=>
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      string(580) "Sleep often invites itself in everyday transport. CC BY 2.0 Ten thousand steps and more. Would sleeping well become a privilege? Already somewhat weighed down in recent years, the sleep of the French has deteriorated further with the pandemic. Currently, nearly two-thirds of adults (63%) report “Sleep problems in the last eight days”, according to ... Read more"
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Ten thousand steps and more. Would sleeping well become a privilege? Already somewhat weighed down in recent years, the sleep of the French has deteriorated further with the pandemic.

Currently, nearly two-thirds of adults (63%) report “Sleep problems in the last eight days”, according to the last wave of the CoviPrev survey, released on September 23. The phenomenon is not temporary. This proportion has remained permanently high (oscillating between 59% and 67%) since the first confinement in March 2020, when Public Health France launched the regular monitoring of a few mental health indicators, monitoring which is based on online questionnaires with ‘samples of 2,000 people over 18 years of age. At the time of the previous survey in the general population, the 2017 Health Barometer, a little less than one in two French people (49.4%) were affected by sleep problems in the previous eight days.

Read also The power of the nap

For a majority of us, it is urgent to set up parades to find more peaceful nights. Maintain regular times of getting up and going to bed, including weekends; exposure to daylight, especially in the morning; make a digital curfew… The rules of hygiene of life promoting a quality sleep are well known, listed for example on the site of the National Institute of Sleep and Vigilance.

Synchronizer of all biological rhythms

Let’s focus on the role of our favorite therapy: physical activity. In individuals with no particular sleep problem, regular movement reduces the time it takes to fall asleep and improves the overall quality of sleep. Regular physical activity especially increases slow deep sleep. Beneficial effects have also been shown in insomniacs or in patients with sleep apnea.

The sleep-physical activity relationship is also bidirectional, as shown in particular a study including more than 38,000 participants in the British Biobank cohort, followed for seven years (Preventive Medicine, volume 143, February 2021).

Read also the interview from 2017: Article reserved for our subscribers “Lack of sleep is killing us”

Compared to people who were very active at the start and end of the study, being physically inactive at baseline and reduced physical activity over time were associated with a higher likelihood of poor sleep during the period. regular. At the same time, participants with “intermediate” or “poor” sleep at baseline had higher risks of physical inactivity at follow-up than those with healthy sleep. The evolution towards healthy sleep over time attenuated these negative associations, the authors point out.

You have 30.8% of this article left to read. The rest is for subscribers only.

We want to give thanks to the author of this write-up for this awesome material

To sleep better, don’t forget to move

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Ten thousand steps and more. Would sleeping well become a privilege? Already somewhat weighed down in recent years, the sleep of the French has deteriorated further with the pandemic.

Currently, nearly two-thirds of adults (63%) report “Sleep problems in the last eight days”, according to the last wave of the CoviPrev survey, released on September 23. The phenomenon is not temporary. This proportion has remained permanently high (oscillating between 59% and 67%) since the first confinement in March 2020, when Public Health France launched the regular monitoring of a few mental health indicators, monitoring which is based on online questionnaires with ‘samples of 2,000 people over 18 years of age. At the time of the previous survey in the general population, the 2017 Health Barometer, a little less than one in two French people (49.4%) were affected by sleep problems in the previous eight days.

Read also The power of the nap

For a majority of us, it is urgent to set up parades to find more peaceful nights. Maintain regular times of getting up and going to bed, including weekends; exposure to daylight, especially in the morning; make a digital curfew… The rules of hygiene of life promoting a quality sleep are well known, listed for example on the site of the National Institute of Sleep and Vigilance.

Synchronizer of all biological rhythms

Let’s focus on the role of our favorite therapy: physical activity. In individuals with no particular sleep problem, regular movement reduces the time it takes to fall asleep and improves the overall quality of sleep. Regular physical activity especially increases slow deep sleep. Beneficial effects have also been shown in insomniacs or in patients with sleep apnea.

The sleep-physical activity relationship is also bidirectional, as shown in particular a study including more than 38,000 participants in the British Biobank cohort, followed for seven years (Preventive Medicine, volume 143, February 2021).

Read also the interview from 2017: Article reserved for our subscribers “Lack of sleep is killing us”

Compared to people who were very active at the start and end of the study, being physically inactive at baseline and reduced physical activity over time were associated with a higher likelihood of poor sleep during the period. regular. At the same time, participants with “intermediate” or “poor” sleep at baseline had higher risks of physical inactivity at follow-up than those with healthy sleep. The evolution towards healthy sleep over time attenuated these negative associations, the authors point out.

You have 30.8% of this article left to read. The rest is for subscribers only.

We want to give thanks to the author of this write-up for this awesome material

To sleep better, don’t forget to move

" ["date_timestamp"]=> int(1635716082) } [1]=> array(11) { ["title"]=> string(74) "Kolik mm protiltek? Lid vyhledvaj testy i kvli tet dvce okovn – iDNES.cz" ["link"]=> string(89) "https://bofads.com/kolik-mm-protiltek-lid-vyhledvaj-testy-i-kvli-tet-dvce-okovn-idnes-cz/" ["dc"]=> array(1) { ["creator"]=> string(8) "Tim Hall" } ["pubdate"]=> string(31) "Sun, 31 Oct 2021 21:33:40 +0000" ["category"]=> string(22) "SportiDNESczKoliktesty" ["guid"]=> string(26) "https://bofads.com/?p=1249" ["description"]=> string(608) "Ml jsem kompletn ukonen okovn ped przdninami, poslze jsem byl zkraje lta na dovolen ve panlsku a kdy jsem se vrtil, ml jsem covid pozitivn test, vyprv Martin M. Prbh nemoci byl leh, ml erven oi, zvenou teplotu, kael. Na dva tdny tak ztratil ich. Pak m kolega v prci navedl, e v mm ppad ... Read more" ["content"]=> array(1) { ["encoded"]=> string(6712) "

Ml jsem kompletn ukonen okovn ped przdninami, poslze jsem byl zkraje lta na dovolen ve panlsku a kdy jsem se vrtil, ml jsem covid pozitivn test, vyprv Martin M. Prbh nemoci byl leh, ml erven oi, zvenou teplotu, kael. Na dva tdny tak ztratil ich.

Pak m kolega v prci navedl, e v mm ppad by mohlo bt zajmav si nechat zmit protiltky, popsal. Vsledek? Vyla mi hodnota 3300 AU/ml, co je hodnoceno jako siln pozitivn na protiltky, dodal.

Za test tehdy zaplatil 450 korun a nyn plnuje, e se nech otestovat na protiltky jet jednou, ale a v dob, kdy bude mt ped tet dvkou vakcny.Pokud je budu mt vysok, zvm, zda jt na tet dvku vakcny, uvedl.

Soud odmtl uznat protiltky. Rozhodl o ji neplatnm opaten

O protiltkch se v esku diskutuje zejmna s ohledem na okovn. Ti, kte se nechali otestovat a vyly jim vysok hodnoty, toti argumentuj, e okovn nepotebuj.

Takto se v minulosti napklad vyjadoval i f SPD Tomio Okamura. Velk zjem o testovn mezi lidmi o protiltky nicmn nen, zejmna kvli tomu, e se protiltky v esku neuznvaj.

Zjem kvli tet dvce

Kad msc otestujeme ni stovky lid, uvedl Michal Mikk, mluv GHC Genetics. Testovn spolenost nabz na svch vybranch odbrovch mstech, napklad na ruzyskm letiti.

Lidi zajm, kolik protiltek se jim vytvoilo po okovn zejmna s ohledem na tet dvku. Mli teba po okovn silnj vedlej reakci a chtj se poradit s lkaem, zda nemaj jet pokat. Dle jsou to lid, kter zase zajm hladina protiltek po prodlanm onemocnn, popsal. Nejmn je tch, kte chtj vyut vsledek pro cestu napklad do Rakouska, kde se protiltky uznvaj.

V lidskm tle se po prodlan infekci objevuje nkolik typ protiltek. Podle toho, jak protiltky chcete zjistit, nabz odbrov zazen rzn testy. Otestovat se nicmn mete i na vechny druhy protiltek.

Napklad Synlab nov od z nabz komplexn test, kter doke rozeznat vce druh protiltek, vetn mutac viru delta. Pacientm tak laborato doke ct, zda je innost jejich protiltek vi delt ni.

Podle Anabely kov, vedouc laboratoe Synlab, lid vyhledvaj testy na prodln kvli tomu, e si chtj ovit, zda nemoc skuten maj za sebou. Protiltky nevydr v tle navky. Vsledky test v Synlabu podle kov potvrzuj, e zvl᚝ u starch lid ochrana poskytnut vakcnou relativn rychle kles.

  • Cena testu na protiltky se li podle odbrov laboratoe a typu odebranch protiltek.
  • Protiltky v tle zstvaj i nkolik let.
  • Test na protiltky si hradte sami.

Doporuujeme pacientm, kte maj protiltky, nebo si je chtj nechat zkontrolovat, cyklus v rozmez t msc, uvedla s tm, e nem smysl chodit na test dv.

Synlab upozoruje, e pokud lovk m protiltky proti onemocnn covid-19, neznamen to, e by se lovk nenakazil. Virem se me lovk nakazit i v ppad vysok hladiny ochrannch ltek, prbh nemoci nicmn bude leh.

Studie protiltek

Jak je to v esku s protiltkami, m tak zjistit studie ministerstva zdravotnictv. Zastnit se j m piblin 8 tisc ech vetn zdravotnk, chronicky nemocnch a lid, kte byli otestovni u v roce 2020 v prvn fzi studie. astnky oslov pmo nemocnice v Praze a Olomouci. Testovalo se v z a v jnu.

Studi na zjitn protiltek projde osm tisc lid. Oslov je nemocnice

Studie nm pome pochopit dynamiku en onemocnn covid-19 v esk republice. A tak nm dod podklady pro een tolik diskutovan otzky uznvn protiltek. Dnes mme toti pouze dl a necentralizovan daje zskan rozdlnmi metodikami a za pouit rznch laboratornch metod, uvedl dve ke studii ministr zdravotnictv Adam Vojtch.

Uznvn protiltek jako alternativy k okovn, negativnmu testu nebo prodlan nemoci v poslednch esti mscch daj u od jara nkter politick strany, premir Andrej Babi i st odbornk. Lid, kte maj dosud vysok protiltky, se toti nkdy nechtj dt okovat.

Hladiny protiltek v esku sleduje mimo jin i vzkumn centrum RECETOX pi Prodovdeck fakult Masarykovy univerzity. V srpnu vdci pod vedenm imunologa Vojtcha Thona publikovali vsledky prvn sti studie, v n zjistili, e letos v beznu mla protiltky proti covidu vce ne polovina z 30 tisc dobrovolnk.

Covid prodlala vce ne polovina lid, ukzala studie hladin protiltek

Zatmco v jnu a listopadu 2020 mlo sledovan protiltky pouze 28 procent dobrovolnk, v prosinci 2020 a lednu 2021 to bylo 43 procent a v noru a beznu 2021 u 51 procent. To znamen, e v beznu 2021 u nebyla podstatn st esk populace k infekci SARS-CoV-2 imunologicky naivn, komentoval tehdy vsledky Thon.

Z toho vyplv, e nejmn jedna tetina astnk, u kterch byly nalezeny protiltky, nezaznamenala dn pznaky onemocnn a 28 procentjedinc s protiltkami nikdy nebylo na PCR testu.

We want to say thanks to the author of this write-up for this outstanding material

Kolik mm protiltek? Lid vyhledvaj testy i kvli tet dvce okovn – iDNES.cz

" } ["summary"]=> string(608) "Ml jsem kompletn ukonen okovn ped przdninami, poslze jsem byl zkraje lta na dovolen ve panlsku a kdy jsem se vrtil, ml jsem covid pozitivn test, vyprv Martin M. Prbh nemoci byl leh, ml erven oi, zvenou teplotu, kael. Na dva tdny tak ztratil ich. Pak m kolega v prci navedl, e v mm ppad ... Read more" ["atom_content"]=> string(6712) "

Ml jsem kompletn ukonen okovn ped przdninami, poslze jsem byl zkraje lta na dovolen ve panlsku a kdy jsem se vrtil, ml jsem covid pozitivn test, vyprv Martin M. Prbh nemoci byl leh, ml erven oi, zvenou teplotu, kael. Na dva tdny tak ztratil ich.

Pak m kolega v prci navedl, e v mm ppad by mohlo bt zajmav si nechat zmit protiltky, popsal. Vsledek? Vyla mi hodnota 3300 AU/ml, co je hodnoceno jako siln pozitivn na protiltky, dodal.

Za test tehdy zaplatil 450 korun a nyn plnuje, e se nech otestovat na protiltky jet jednou, ale a v dob, kdy bude mt ped tet dvkou vakcny.Pokud je budu mt vysok, zvm, zda jt na tet dvku vakcny, uvedl.

Soud odmtl uznat protiltky. Rozhodl o ji neplatnm opaten

O protiltkch se v esku diskutuje zejmna s ohledem na okovn. Ti, kte se nechali otestovat a vyly jim vysok hodnoty, toti argumentuj, e okovn nepotebuj.

Takto se v minulosti napklad vyjadoval i f SPD Tomio Okamura. Velk zjem o testovn mezi lidmi o protiltky nicmn nen, zejmna kvli tomu, e se protiltky v esku neuznvaj.

Zjem kvli tet dvce

Kad msc otestujeme ni stovky lid, uvedl Michal Mikk, mluv GHC Genetics. Testovn spolenost nabz na svch vybranch odbrovch mstech, napklad na ruzyskm letiti.

Lidi zajm, kolik protiltek se jim vytvoilo po okovn zejmna s ohledem na tet dvku. Mli teba po okovn silnj vedlej reakci a chtj se poradit s lkaem, zda nemaj jet pokat. Dle jsou to lid, kter zase zajm hladina protiltek po prodlanm onemocnn, popsal. Nejmn je tch, kte chtj vyut vsledek pro cestu napklad do Rakouska, kde se protiltky uznvaj.

V lidskm tle se po prodlan infekci objevuje nkolik typ protiltek. Podle toho, jak protiltky chcete zjistit, nabz odbrov zazen rzn testy. Otestovat se nicmn mete i na vechny druhy protiltek.

Napklad Synlab nov od z nabz komplexn test, kter doke rozeznat vce druh protiltek, vetn mutac viru delta. Pacientm tak laborato doke ct, zda je innost jejich protiltek vi delt ni.

Podle Anabely kov, vedouc laboratoe Synlab, lid vyhledvaj testy na prodln kvli tomu, e si chtj ovit, zda nemoc skuten maj za sebou. Protiltky nevydr v tle navky. Vsledky test v Synlabu podle kov potvrzuj, e zvl᚝ u starch lid ochrana poskytnut vakcnou relativn rychle kles.

  • Cena testu na protiltky se li podle odbrov laboratoe a typu odebranch protiltek.
  • Protiltky v tle zstvaj i nkolik let.
  • Test na protiltky si hradte sami.

Doporuujeme pacientm, kte maj protiltky, nebo si je chtj nechat zkontrolovat, cyklus v rozmez t msc, uvedla s tm, e nem smysl chodit na test dv.

Synlab upozoruje, e pokud lovk m protiltky proti onemocnn covid-19, neznamen to, e by se lovk nenakazil. Virem se me lovk nakazit i v ppad vysok hladiny ochrannch ltek, prbh nemoci nicmn bude leh.

Studie protiltek

Jak je to v esku s protiltkami, m tak zjistit studie ministerstva zdravotnictv. Zastnit se j m piblin 8 tisc ech vetn zdravotnk, chronicky nemocnch a lid, kte byli otestovni u v roce 2020 v prvn fzi studie. astnky oslov pmo nemocnice v Praze a Olomouci. Testovalo se v z a v jnu.

Studi na zjitn protiltek projde osm tisc lid. Oslov je nemocnice

Studie nm pome pochopit dynamiku en onemocnn covid-19 v esk republice. A tak nm dod podklady pro een tolik diskutovan otzky uznvn protiltek. Dnes mme toti pouze dl a necentralizovan daje zskan rozdlnmi metodikami a za pouit rznch laboratornch metod, uvedl dve ke studii ministr zdravotnictv Adam Vojtch.

Uznvn protiltek jako alternativy k okovn, negativnmu testu nebo prodlan nemoci v poslednch esti mscch daj u od jara nkter politick strany, premir Andrej Babi i st odbornk. Lid, kte maj dosud vysok protiltky, se toti nkdy nechtj dt okovat.

Hladiny protiltek v esku sleduje mimo jin i vzkumn centrum RECETOX pi Prodovdeck fakult Masarykovy univerzity. V srpnu vdci pod vedenm imunologa Vojtcha Thona publikovali vsledky prvn sti studie, v n zjistili, e letos v beznu mla protiltky proti covidu vce ne polovina z 30 tisc dobrovolnk.

Covid prodlala vce ne polovina lid, ukzala studie hladin protiltek

Zatmco v jnu a listopadu 2020 mlo sledovan protiltky pouze 28 procent dobrovolnk, v prosinci 2020 a lednu 2021 to bylo 43 procent a v noru a beznu 2021 u 51 procent. To znamen, e v beznu 2021 u nebyla podstatn st esk populace k infekci SARS-CoV-2 imunologicky naivn, komentoval tehdy vsledky Thon.

Z toho vyplv, e nejmn jedna tetina astnk, u kterch byly nalezeny protiltky, nezaznamenala dn pznaky onemocnn a 28 procentjedinc s protiltkami nikdy nebylo na PCR testu.

We want to say thanks to the author of this write-up for this outstanding material

Kolik mm protiltek? Lid vyhledvaj testy i kvli tet dvce okovn – iDNES.cz

" ["date_timestamp"]=> int(1635716020) } [2]=> array(11) { ["title"]=> string(60) "We’ve selected new artists who are renewing soul and jazz." ["link"]=> string(76) "https://bofads.com/weve-selected-new-artists-who-are-renewing-soul-and-jazz/" ["dc"]=> array(1) { ["creator"]=> string(12) "Paula Hooper" } ["pubdate"]=> string(31) "Sun, 31 Oct 2021 21:31:21 +0000" ["category"]=> string(36) "MusicartistsJazzrenewingselectedsoul" ["guid"]=> string(26) "https://bofads.com/?p=1246" ["description"]=> string(603) "short Music Non Stop no Facebook The new always comes! Time to meet new artists who are doing very well in soul and jazz. A lot of people ask me what I’m listening to now, what’s new, or say there’s nothing worthwhile new. I decided to write today’s column mainly to contradict the last statement. ... Read more" ["content"]=> array(1) { ["encoded"]=> string(20959) "

The new always comes! Time to meet new artists who are doing very well in soul and jazz.

A lot of people ask me what I’m listening to now, what’s new, or say there’s nothing worthwhile new. I decided to write today’s column mainly to contradict the last statement. They do have and as they have, a lot of good stuff, to show you a little bit of what I’ve been listening to, here’s a small collection of very cool sounds in soul and jazz released recently.

Martyr Luther King speaking

Jazz is Dead

Jazz is Dead 4 - Azymuth

Imagem: Jazz is Dead 4

I’ve already started this list with a seven-disc collection so you can see I’m not kidding. Ali Shaheed Muhammad e Adrian Younge, multi instrumentalists and producers linked mainly to Hip Hop, got together in 2017 to produce a series of shows with some jazz legends. The shows became records, released in 2020, making Jazz is Dead a stamp. I recommend all of them, but I highlight some songs, they are: Conexão, in partnership with John Donato; the psychedelic jazz of Apocalyptic, with the genius Azymuth; That’s what I know, with Marcos Valle,  Lions Walk, com Doug Carn and Distant Mode, with Gary Bartz. The Brazilians absolutely rocked and if I had to choose just one, it would be Azymuth. The irony in the name is, of course, purposeful, Jazz isn’t even close to being dead and Jazz is Dead (1-7) are there to prove it.

Mulatu Astake & Black Jesus

Mulatu Astake & Black Jesus

photo: disclosure

In partnership with the collective Black Jesus Experience, formed by singers, rappers and jazz musicians from Morocco, Australia, Zimbabwe and Ethiopia, the veteran multi-instrumentalist and composer released the album To Know Without Knowing, in 2020, on Agogo Records. The album, fluctuating in a good way between the old and the modern, grooved, has the ethio jazz touch typical of Mulatu, but that’s not all. The vocals, in addition to being beautiful, are mesmerizing and the album is seasoned with rock, funk and hip hop in a delicious alchemy.

Count Favela Sextet

Count Favela Sextet

photo: Fernando Lago

The album Themes for Times of War, released in 2020, it emerged in response to the death of a family shot 80 times by the army in Rio de Janeiro. The sextet was born in the ABC Paulista and, influenced by bebop, hardbop and freejazz, they move between samba jazz, spiritual jazz, improvisation and the erudite with creativity, rebellion and a lot of beauty. Formed by Alex Days (low), Diego Estevam (guitar), Mabu Reis (trombone), Harlem Birth (sax tenor), Rafael Cab (drums), Edson One (trumpet), the band recently released, on the Sesc platform, the performance video Jazz Pra Que? With reflections on jazz, its origins, legacy and, of course, excerpts from the new album.

I’m a big fan of Conde Favela, after 11 years of career, the release of Temas para Tempos de Guerra is one of the best current albums and comes to establish them once and for all on this road.

Nubya garcia

Nubya garcia

photo: disclosure

After two successful EPs (Nubya’s 5ive, in 2017 and When We Are, 2018), the saxophonist and composer finally released, in 2020 the album Source and it’s beautiful: it lives up to the title and mixes everything very well, in a delicious sauce of cumbia, dub, jazz, soul and electronic . Nubya’s sax is the balance of the entire record.

Among the musicians who collaborate are Joe Armon Jones, keyboardist of Ezra Collective, who released the debut album You Can’t Steal My Joy in 2019) and the trumpeter Sheyla Maurice Gray , band leader Kokoroko and member of the septet Nérija, collective formed mainly by women, which also released an album, in 2019, Blume, by Domino Records, with beautiful melodies marked by metals, I indicate a lot, I loved this album.

Bufo Borealis

Bufo Borealis

photo: disclosure

Horizontal pupils, the debut album of Bufo Borealis, formed by Rodrigo Saldanha (Invisible Friends) and Juninho Sangiorgio (Ratos de Porão), released in May 2020, it’s surprising, the punk that comes in the musicians’ baggage sets the tone for this great jazz record, full of cool participations like Edgard Scandurra (Ira!), Rodrigo Carneiro (Mickey Junkies), Roger Martins (Hurtmold) e Fernanda Lira (Crypta), among others.

Jazz has always been present on the duo’s record players, who cooked up the idea and the desire to put into practice an album in the style for years, edited, recorded, conceived everything themselves, the result of this enthusiasm and involvement is noticeable on the record. Punk and Jazz have their similarities, not in the melody, but in the posture, the search for freedom, the mix is ​​nothing new and I think it all starts back in the 1960s with Ornette Colleman entering the studio with other musicians and coming out with a revolutionary piece by 37 minutes, but that’s a subject for another text. Bufo Borealis is punk, it’s jazz and it’s very good.

Archie Shepp

photo: disclosure

The legendary saxophonist teams up with his nephew Jason Moore, better known as Raw Poetic on vocals, Damu The Fudgemunk drums and vibraphones, contributors of completely different sensibilities and stories, result in a delicious hip hop jazz album. Shepp, one of the pioneers of Free Jazz, now 84 years old, says that performing this project alongside these young musicians is absolutely wonderful in itself. Not only that, the 66-minute disc is still vigorous, with raw improvisations in a smooth mix, where you can feel the signature of each artist naturally, the respect and admiration for the master is remarkable, some tracks are called Professor Shepp’s Agenda and they are pure free jazz delight.

Dynamite Combo

Dynamite Combo

photo: disclosure

I challenge you to put the sound of the new single released by the band from Curitiba and be able to stay seated. Keep away the furniture that Danger Zone, masterfully produced by DJ Hum, it’s a total breaker. In 2019, the band released the single Blow Thy Horns/Life is Hard with their own compositions, now in 2021, Danger Zone, letter of Willie Dinamite, who also does the band’s vocals and composition in partnership with Dj Hum, has as its main theme the pandemic that we are unfortunately experiencing. The sextet composed of Caetano Zagonel (low), Anderson Limax (guiyarra), Menander Souza (Trumpet), Rodrigo Nickel (sax), Yuri Vasselai (battery), and Willie Dinamite already mentioned, makes a soul of respect, just released the single and we already want an entire album yes!

Dr Loonie Smith

Lonnie Smith e Iggy Pop

Lonnie Smith (right) and Iggy Pop – photo: disclosure

Finally, I write these words with a mixture of sadness and joy. Sadness for the recent death of this master of groove, joy that he left us this last gift. And what a gift! The acclaimed organist’s third album Breathe on Blue Note Records combines live and studio tracks, opens and closes with the participation of Iggy Pop no vocal dos covers do hit soul de Timmy Thomas, Why Can´t We Live Togheter (1972) e o de Donovan , Sunshine Superman (1966).

The album was carefully produced by the president of Blue Note, Don Was and also features some songs recorded during Smith’s 75th birthday celebration in 2017, the same week he entered the studio for the acclaimed album All in My Mind.

Breathe is beautiful, I heard moved by the dynamism of this wizard from Hammond B3, especially in Bright Eyes, a composition by Smith that became known as George Benson and here it’s a very elegant mix of jazz and soul; I also highlight Epistrophy, composed by Thelonious Monk e Kenny Clarke in 1941, performed on this album in an incredible funky outfit. Between regret and thanks for such a wonderful work, listen Dr Lonnie Smith in the last volume. Good trip.

I could write several more lines about each of the above quotes and also indicate a lot more great stuff coming out this year, or coming out recently. There is a lot more: Kamasi Washington launched Sun Kissed Child; Amaro Freitas with the beautiful and improved Sankofa; William Parker with the intense Mayan Space Station, ou o delicioso Take Root Among The Stars, do Roots Magic that came out in 2020, and so on…

It was kind of difficult to choose just a few, but the choices I made were thought out with great care, some by jazz as a lifestyle, blood, sweat, tears and a lot of love for music, especially here in Brazil, especially now, in front of a government that discourages any art form, to say the least.

Save whoever makes the music happen, whoever keeps jazz and soul alive and look, from the list above, they’re more alive than ever.

Adriana Arakake

Adriana Ararake is a DJ specializing in Jazz, Soul and Blues for Music Non Stop.

We want to say thanks to the author of this article for this outstanding web content

We’ve selected new artists who are renewing soul and jazz.

" } ["summary"]=> string(603) "short Music Non Stop no Facebook The new always comes! Time to meet new artists who are doing very well in soul and jazz. A lot of people ask me what I’m listening to now, what’s new, or say there’s nothing worthwhile new. I decided to write today’s column mainly to contradict the last statement. ... Read more" ["atom_content"]=> string(20959) "

The new always comes! Time to meet new artists who are doing very well in soul and jazz.

A lot of people ask me what I’m listening to now, what’s new, or say there’s nothing worthwhile new. I decided to write today’s column mainly to contradict the last statement. They do have and as they have, a lot of good stuff, to show you a little bit of what I’ve been listening to, here’s a small collection of very cool sounds in soul and jazz released recently.

Martyr Luther King speaking

Jazz is Dead

Jazz is Dead 4 - Azymuth

Imagem: Jazz is Dead 4

I’ve already started this list with a seven-disc collection so you can see I’m not kidding. Ali Shaheed Muhammad e Adrian Younge, multi instrumentalists and producers linked mainly to Hip Hop, got together in 2017 to produce a series of shows with some jazz legends. The shows became records, released in 2020, making Jazz is Dead a stamp. I recommend all of them, but I highlight some songs, they are: Conexão, in partnership with John Donato; the psychedelic jazz of Apocalyptic, with the genius Azymuth; That’s what I know, with Marcos Valle,  Lions Walk, com Doug Carn and Distant Mode, with Gary Bartz. The Brazilians absolutely rocked and if I had to choose just one, it would be Azymuth. The irony in the name is, of course, purposeful, Jazz isn’t even close to being dead and Jazz is Dead (1-7) are there to prove it.

Mulatu Astake & Black Jesus

Mulatu Astake & Black Jesus

photo: disclosure

In partnership with the collective Black Jesus Experience, formed by singers, rappers and jazz musicians from Morocco, Australia, Zimbabwe and Ethiopia, the veteran multi-instrumentalist and composer released the album To Know Without Knowing, in 2020, on Agogo Records. The album, fluctuating in a good way between the old and the modern, grooved, has the ethio jazz touch typical of Mulatu, but that’s not all. The vocals, in addition to being beautiful, are mesmerizing and the album is seasoned with rock, funk and hip hop in a delicious alchemy.

Count Favela Sextet

Count Favela Sextet

photo: Fernando Lago

The album Themes for Times of War, released in 2020, it emerged in response to the death of a family shot 80 times by the army in Rio de Janeiro. The sextet was born in the ABC Paulista and, influenced by bebop, hardbop and freejazz, they move between samba jazz, spiritual jazz, improvisation and the erudite with creativity, rebellion and a lot of beauty. Formed by Alex Days (low), Diego Estevam (guitar), Mabu Reis (trombone), Harlem Birth (sax tenor), Rafael Cab (drums), Edson One (trumpet), the band recently released, on the Sesc platform, the performance video Jazz Pra Que? With reflections on jazz, its origins, legacy and, of course, excerpts from the new album.

I’m a big fan of Conde Favela, after 11 years of career, the release of Temas para Tempos de Guerra is one of the best current albums and comes to establish them once and for all on this road.

Nubya garcia

Nubya garcia

photo: disclosure

After two successful EPs (Nubya’s 5ive, in 2017 and When We Are, 2018), the saxophonist and composer finally released, in 2020 the album Source and it’s beautiful: it lives up to the title and mixes everything very well, in a delicious sauce of cumbia, dub, jazz, soul and electronic . Nubya’s sax is the balance of the entire record.

Among the musicians who collaborate are Joe Armon Jones, keyboardist of Ezra Collective, who released the debut album You Can’t Steal My Joy in 2019) and the trumpeter Sheyla Maurice Gray , band leader Kokoroko and member of the septet Nérija, collective formed mainly by women, which also released an album, in 2019, Blume, by Domino Records, with beautiful melodies marked by metals, I indicate a lot, I loved this album.

Bufo Borealis

Bufo Borealis

photo: disclosure

Horizontal pupils, the debut album of Bufo Borealis, formed by Rodrigo Saldanha (Invisible Friends) and Juninho Sangiorgio (Ratos de Porão), released in May 2020, it’s surprising, the punk that comes in the musicians’ baggage sets the tone for this great jazz record, full of cool participations like Edgard Scandurra (Ira!), Rodrigo Carneiro (Mickey Junkies), Roger Martins (Hurtmold) e Fernanda Lira (Crypta), among others.

Jazz has always been present on the duo’s record players, who cooked up the idea and the desire to put into practice an album in the style for years, edited, recorded, conceived everything themselves, the result of this enthusiasm and involvement is noticeable on the record. Punk and Jazz have their similarities, not in the melody, but in the posture, the search for freedom, the mix is ​​nothing new and I think it all starts back in the 1960s with Ornette Colleman entering the studio with other musicians and coming out with a revolutionary piece by 37 minutes, but that’s a subject for another text. Bufo Borealis is punk, it’s jazz and it’s very good.

Archie Shepp

photo: disclosure

The legendary saxophonist teams up with his nephew Jason Moore, better known as Raw Poetic on vocals, Damu The Fudgemunk drums and vibraphones, contributors of completely different sensibilities and stories, result in a delicious hip hop jazz album. Shepp, one of the pioneers of Free Jazz, now 84 years old, says that performing this project alongside these young musicians is absolutely wonderful in itself. Not only that, the 66-minute disc is still vigorous, with raw improvisations in a smooth mix, where you can feel the signature of each artist naturally, the respect and admiration for the master is remarkable, some tracks are called Professor Shepp’s Agenda and they are pure free jazz delight.

Dynamite Combo

Dynamite Combo

photo: disclosure

I challenge you to put the sound of the new single released by the band from Curitiba and be able to stay seated. Keep away the furniture that Danger Zone, masterfully produced by DJ Hum, it’s a total breaker. In 2019, the band released the single Blow Thy Horns/Life is Hard with their own compositions, now in 2021, Danger Zone, letter of Willie Dinamite, who also does the band’s vocals and composition in partnership with Dj Hum, has as its main theme the pandemic that we are unfortunately experiencing. The sextet composed of Caetano Zagonel (low), Anderson Limax (guiyarra), Menander Souza (Trumpet), Rodrigo Nickel (sax), Yuri Vasselai (battery), and Willie Dinamite already mentioned, makes a soul of respect, just released the single and we already want an entire album yes!

Dr Loonie Smith

Lonnie Smith e Iggy Pop

Lonnie Smith (right) and Iggy Pop – photo: disclosure

Finally, I write these words with a mixture of sadness and joy. Sadness for the recent death of this master of groove, joy that he left us this last gift. And what a gift! The acclaimed organist’s third album Breathe on Blue Note Records combines live and studio tracks, opens and closes with the participation of Iggy Pop no vocal dos covers do hit soul de Timmy Thomas, Why Can´t We Live Togheter (1972) e o de Donovan , Sunshine Superman (1966).

The album was carefully produced by the president of Blue Note, Don Was and also features some songs recorded during Smith’s 75th birthday celebration in 2017, the same week he entered the studio for the acclaimed album All in My Mind.

Breathe is beautiful, I heard moved by the dynamism of this wizard from Hammond B3, especially in Bright Eyes, a composition by Smith that became known as George Benson and here it’s a very elegant mix of jazz and soul; I also highlight Epistrophy, composed by Thelonious Monk e Kenny Clarke in 1941, performed on this album in an incredible funky outfit. Between regret and thanks for such a wonderful work, listen Dr Lonnie Smith in the last volume. Good trip.

I could write several more lines about each of the above quotes and also indicate a lot more great stuff coming out this year, or coming out recently. There is a lot more: Kamasi Washington launched Sun Kissed Child; Amaro Freitas with the beautiful and improved Sankofa; William Parker with the intense Mayan Space Station, ou o delicioso Take Root Among The Stars, do Roots Magic that came out in 2020, and so on…

It was kind of difficult to choose just a few, but the choices I made were thought out with great care, some by jazz as a lifestyle, blood, sweat, tears and a lot of love for music, especially here in Brazil, especially now, in front of a government that discourages any art form, to say the least.

Save whoever makes the music happen, whoever keeps jazz and soul alive and look, from the list above, they’re more alive than ever.

Adriana Arakake

Adriana Ararake is a DJ specializing in Jazz, Soul and Blues for Music Non Stop.

We want to say thanks to the author of this article for this outstanding web content

We’ve selected new artists who are renewing soul and jazz.

" ["date_timestamp"]=> int(1635715881) } [3]=> array(11) { ["title"]=> string(75) "New Google Nest Hub coming to Belgium on May 4 (and doing it in your sleep)" ["link"]=> string(93) "https://bofads.com/new-google-nest-hub-coming-to-belgium-on-may-4-and-doing-it-in-your-sleep/" ["dc"]=> array(1) { ["creator"]=> string(11) "David Lonit" } ["pubdate"]=> string(31) "Sun, 31 Oct 2021 21:29:56 +0000" ["category"]=> string(38) "GadgetsBelgiumcomingGoogleHubNestsleep" ["guid"]=> string(26) "https://bofads.com/?p=1243" ["description"]=> string(648) "The second generation of the Nest Hub, Google’s smart speaker with a 7-inch touchscreen, will also be available in our country from May 4. The main novelty is the Sleep Sensing function that analyzes the user’s sleep pattern. The improved Nest Hub was already introduced in the United States at the end of March. On ... Read more" ["content"]=> array(1) { ["encoded"]=> string(4213) "

The second generation of the Nest Hub, Google’s smart speaker with a 7-inch touchscreen, will also be available in our country from May 4. The main novelty is the Sleep Sensing function that analyzes the user’s sleep pattern.

The improved Nest Hub was already introduced in the United States at the end of March. On the outside there are hardly any differences with the original model, but the gadget did get a better speaker that, according to Google, delivers fifty percent more bass.

bedroom toy

Although you can place the Nest Hub anywhere in the house, for example as a digital photo frame or simply as a central voice assistant, the new model explicitly applies for a place in the bedroom. Witness to this is the Sleep Sensing function that analyzes how the person closest to the display sleeps at night.

The Hub uses Motion Sense for this: a combination of integrated microphones and ambient light and temperature sensors that can also detect disturbances in sleep, such as coughing, snoring or changes in light and temperature. The aim is to help you better understand which factors influence your sleep. Every morning the screen shows a personal overview of your sleep data.

Privacy guaranteed

Google emphasizes that the privacy of the user is guaranteed. ‘Motion Sense only detects movement, not specific bodies or faces. The audio data from coughing and snoring is only processed on the device and therefore not sent to Google’s servers,” it sounds. Users can also disable the sleep detection completely and delete the logged data at any time.

The gadget will be available from May 4 in the colors Chalk and Charcoal and will receive a target price of 99 euros.

The improved Nest Hub was already introduced in the United States at the end of March. On the outside there are hardly any differences with the original model, but the gadget did get a better speaker that, according to Google, delivers fifty percent more bass.Although you can place the Nest Hub anywhere in the house, for example as a digital photo frame or simply as a central voice assistant , the new model explicitly applies for a place in the bedroom. A testament to this is the Sleep Sensing function that analyzes at night how the person closest to the display sleeps. The Hub uses Motion Sense: a combination of integrated microphones and ambient light and temperature sensors that also detect disturbances from detect sleep, such as coughing, snoring, or changes in light and temperature. The aim is to help you better understand which factors influence your sleep. Every morning the screen shows a personal overview of your sleep data. Google emphasizes that the privacy of the user is guaranteed. ‘Motion Sense only detects movement, not specific bodies or faces. The audio data from coughing and snoring is only processed on the device and therefore not sent to Google’s servers,” it sounds. Users can also disable the sleep detection completely and delete the logged data at any time. The gadget will be available from May 4 in the colors Chalk and Charcoal and will receive a target price of 99 euros.

We want to say thanks to the writer of this article for this incredible material

New Google Nest Hub coming to Belgium on May 4 (and doing it in your sleep)

" } ["summary"]=> string(648) "The second generation of the Nest Hub, Google’s smart speaker with a 7-inch touchscreen, will also be available in our country from May 4. The main novelty is the Sleep Sensing function that analyzes the user’s sleep pattern. The improved Nest Hub was already introduced in the United States at the end of March. On ... Read more" ["atom_content"]=> string(4213) "

The second generation of the Nest Hub, Google’s smart speaker with a 7-inch touchscreen, will also be available in our country from May 4. The main novelty is the Sleep Sensing function that analyzes the user’s sleep pattern.

The improved Nest Hub was already introduced in the United States at the end of March. On the outside there are hardly any differences with the original model, but the gadget did get a better speaker that, according to Google, delivers fifty percent more bass.

bedroom toy

Although you can place the Nest Hub anywhere in the house, for example as a digital photo frame or simply as a central voice assistant, the new model explicitly applies for a place in the bedroom. Witness to this is the Sleep Sensing function that analyzes how the person closest to the display sleeps at night.

The Hub uses Motion Sense for this: a combination of integrated microphones and ambient light and temperature sensors that can also detect disturbances in sleep, such as coughing, snoring or changes in light and temperature. The aim is to help you better understand which factors influence your sleep. Every morning the screen shows a personal overview of your sleep data.

Privacy guaranteed

Google emphasizes that the privacy of the user is guaranteed. ‘Motion Sense only detects movement, not specific bodies or faces. The audio data from coughing and snoring is only processed on the device and therefore not sent to Google’s servers,” it sounds. Users can also disable the sleep detection completely and delete the logged data at any time.

The gadget will be available from May 4 in the colors Chalk and Charcoal and will receive a target price of 99 euros.

The improved Nest Hub was already introduced in the United States at the end of March. On the outside there are hardly any differences with the original model, but the gadget did get a better speaker that, according to Google, delivers fifty percent more bass.Although you can place the Nest Hub anywhere in the house, for example as a digital photo frame or simply as a central voice assistant , the new model explicitly applies for a place in the bedroom. A testament to this is the Sleep Sensing function that analyzes at night how the person closest to the display sleeps. The Hub uses Motion Sense: a combination of integrated microphones and ambient light and temperature sensors that also detect disturbances from detect sleep, such as coughing, snoring, or changes in light and temperature. The aim is to help you better understand which factors influence your sleep. Every morning the screen shows a personal overview of your sleep data. Google emphasizes that the privacy of the user is guaranteed. ‘Motion Sense only detects movement, not specific bodies or faces. The audio data from coughing and snoring is only processed on the device and therefore not sent to Google’s servers,” it sounds. Users can also disable the sleep detection completely and delete the logged data at any time. The gadget will be available from May 4 in the colors Chalk and Charcoal and will receive a target price of 99 euros.

We want to say thanks to the writer of this article for this incredible material

New Google Nest Hub coming to Belgium on May 4 (and doing it in your sleep)

" ["date_timestamp"]=> int(1635715796) } [4]=> array(11) { ["title"]=> string(80) "Proof in produce: Voucher program may help diabetes patients manage their health" ["link"]=> string(99) "https://bofads.com/proof-in-produce-voucher-program-may-help-diabetes-patients-manage-their-health/" ["dc"]=> array(1) { ["creator"]=> string(12) "Tony Grantly" } ["pubdate"]=> string(31) "Sun, 31 Oct 2021 20:39:35 +0000" ["category"]=> string(72) "Health And SciencediabeteshealthmanagepatientsproduceprogramProofVoucher" ["guid"]=> string(26) "https://bofads.com/?p=1241" ["description"]=> string(762) "Journal Reference: Susan Veldheer, Christina Scartozzi, Candace R. Bordner, Chinwendu Opara, Brittany Williams, Lisa Weaver, Diana Rodriguez, Arthur Berg, Christopher Sciamanna. Impact of a Prescription Produce Program on Diabetes and Cardiovascular Risk Outcomes. Journal of Nutrition Education and Behavior, 2021; DOI: 10.1016/j.jneb.2021.07.005 Yield: The Veggie Rx program at Penn State Health St. Joseph Downtown Campus. ... Read more" ["content"]=> array(1) { ["encoded"]=> string(7599) "

Journal Reference:

  1. Susan Veldheer, Christina Scartozzi, Candace R. Bordner, Chinwendu Opara, Brittany Williams, Lisa Weaver, Diana Rodriguez, Arthur Berg, Christopher Sciamanna. Impact of a Prescription Produce Program on Diabetes and Cardiovascular Risk Outcomes. Journal of Nutrition Education and Behavior, 2021; DOI: 10.1016/j.jneb.2021.07.005

Yield: The Veggie Rx program at Penn State Health St. Joseph Downtown Campus.

It began in 2018 when the United Way of Berks County helped Lisa Weaver, a healthy community program associate with Penn State Berks LaunchBox, and a team of clinicians from Penn State Health St. Joseph and students from Penn State Berks launch a pilot program through which patients with chronic obesity and diabetes were offered vouchers as a way to improve their access to fresh fruits and vegetables.

“Community members who seek care at our downtown campus may not have easy access to produce for one reason or another,” Weaver said. “Our goal is to provide patients with resources to find nutrition that might help them live a healthier life, and ultimately lead to improved health outcomes and decreased health care costs.”

A passion for produce

Weaver and her colleagues teamed up with Susan Veldheer and other researchers from Penn State College of Medicine to analyze the pilot program data and figure out if the program was achieving its intended goals.

Veldheer, an assistant professor of family and community medicine and public health sciences, is a registered dietician with a passion for produce and research. She previously analyzed 27 different produce programs, similar to Veggie Rx, from various health care organizations to see whether they were making an impact on patients’ diet and health.

“We learned that many of these programs weren’t designed in ways that could effectively measure their success,” Veldheer said. “Through our Family and Community Medicine colleagues at Penn State Health St. Joseph, we were able to use rigorous research methods to help assess whether Veggie Rx was helping improve the health of patients with diabetes.”

The Veggie Rx team worked with the researchers to answer some key questions coordinators had about the program: Were patients with chronic disease learning better nutrition? Were they redeeming the vouchers they received? Was it helping them reduce their blood pressure or blood sugar levels?

Prescription: fresh fruits and veggies

For seven months, the researchers followed participants who were at least 18 years old with a diagnosis of Type 2 diabetes that met certain clinical criteria. Doctors gave participants vouchers that could be redeemed for produce from certain vendors at three farmers markets in downtown Reading — one at the Farm Stand at the Downtown Campus, another at the Penn Street Market and the last at the Boscov’s Fairgrounds Farmers Market.

The participants — a significant portion of them Hispanic and Latino — received an initial set of produce vouchers — valued at two dollars each — and received more when they showed up for diabetes self-management education sessions. The classes, led by a dietitian and translated into Spanish by a community health worker, covered topics ranging from food preparation and nutrition to physical exercise.

“Hispanic and Latino individuals are more likely to be economically disadvantaged and have diabetes,” Veldheer said. “When you combine those factors, they’re at high risk because they may not be able to afford the optimal nutrition they need to manage their condition.”

Measuring success

At the beginning and end of the seven-month period, the researchers measured patients’ nutrition knowledge, body mass index, blood pressure and hemoglobin A1c — a blood test that measures average blood sugar levels over the past three months. The research team published the results of their study in the Journal of Nutrition Education and Behavior.

Between July 2018 and December 2019, more than 22,500 vouchers were redeemed, equaling more than $45,000 in produce being purchased from Reading area retailers and vendors. Approximately 78% of the distributed vouchers were redeemed for fresh fruits and vegetables.

“That’s a high redemption rate compared to what other similar studies have reported,” Weaver said.

“We also found that voucher redemption was significantly related to a decrease in A1c, which suggests that the vouchers paired with nutrition education helped some patients better manage their diabetes while participating,” Veldheer added.

A future of food as medicine

The research team has big plans for Veggie Rx. They’re converting to a hybrid in-person and virtual format for participants in light of the COVID-19 pandemic and hope to improve their data collection to continue evaluating whether the vouchers and diabetes self-management sessions are helping participants improve their health. They have also applied for funding from the National Institutes of Health (NIH) to conduct a clinical trial on the program. By designing a study that accounts for other factors like attendance at nutrition education sessions, differences in voucher redemption rates and changes in medication, the researchers hope to better measure Veggie Rx’s role in patients’ health.

“This project supports the NIH’s strategic plan for nutrition research, which seeks to improve existing evidence on the benefits of food-as-medicine programs in clinical settings,” Veldheer said. “It also fits into the College of Medicine’s strategic plan, which emphasizes research into new ways to manage chronic illnesses and address health disparities.”

“Food access and food insecurity is a worry for many residents in Reading,” Weaver said. “We hope that by providing easier access to fresh, nutritious produce it will lead to lifestyle changes and better health. We’re thrilled with the results to date and look forward to continuing our strategic community partnerships needed to sustain the program long-term.”

Christina Scartozzi, Candace Bordner, Diana Rodriguez, Arthur Berg and Christopher Sciamanna of Penn State College of Medicine; Chinwendu Opara of WellSpan Medical Group; and Brittany Williams of Lehigh Valley Health Network also contributed to this research.

This research was supported by the United Way of Berks County; The Centers for Disease Control and Prevention, Racial and Ethnic Approaches to Community Health (REACH) program (award number #6 NU 58DP 006587-01-01); the Penn State Leaman Endowment Research Award; and Penn State College of Medicine’s Department of Family and Community Medicine. The authors declare no conflicts of interest.

We want to thank the writer of this article for this amazing web content

Proof in produce: Voucher program may help diabetes patients manage their health

" } ["summary"]=> string(762) "Journal Reference: Susan Veldheer, Christina Scartozzi, Candace R. Bordner, Chinwendu Opara, Brittany Williams, Lisa Weaver, Diana Rodriguez, Arthur Berg, Christopher Sciamanna. Impact of a Prescription Produce Program on Diabetes and Cardiovascular Risk Outcomes. Journal of Nutrition Education and Behavior, 2021; DOI: 10.1016/j.jneb.2021.07.005 Yield: The Veggie Rx program at Penn State Health St. Joseph Downtown Campus. ... Read more" ["atom_content"]=> string(7599) "

Journal Reference:

  1. Susan Veldheer, Christina Scartozzi, Candace R. Bordner, Chinwendu Opara, Brittany Williams, Lisa Weaver, Diana Rodriguez, Arthur Berg, Christopher Sciamanna. Impact of a Prescription Produce Program on Diabetes and Cardiovascular Risk Outcomes. Journal of Nutrition Education and Behavior, 2021; DOI: 10.1016/j.jneb.2021.07.005

Yield: The Veggie Rx program at Penn State Health St. Joseph Downtown Campus.

It began in 2018 when the United Way of Berks County helped Lisa Weaver, a healthy community program associate with Penn State Berks LaunchBox, and a team of clinicians from Penn State Health St. Joseph and students from Penn State Berks launch a pilot program through which patients with chronic obesity and diabetes were offered vouchers as a way to improve their access to fresh fruits and vegetables.

“Community members who seek care at our downtown campus may not have easy access to produce for one reason or another,” Weaver said. “Our goal is to provide patients with resources to find nutrition that might help them live a healthier life, and ultimately lead to improved health outcomes and decreased health care costs.”

A passion for produce

Weaver and her colleagues teamed up with Susan Veldheer and other researchers from Penn State College of Medicine to analyze the pilot program data and figure out if the program was achieving its intended goals.

Veldheer, an assistant professor of family and community medicine and public health sciences, is a registered dietician with a passion for produce and research. She previously analyzed 27 different produce programs, similar to Veggie Rx, from various health care organizations to see whether they were making an impact on patients’ diet and health.

“We learned that many of these programs weren’t designed in ways that could effectively measure their success,” Veldheer said. “Through our Family and Community Medicine colleagues at Penn State Health St. Joseph, we were able to use rigorous research methods to help assess whether Veggie Rx was helping improve the health of patients with diabetes.”

The Veggie Rx team worked with the researchers to answer some key questions coordinators had about the program: Were patients with chronic disease learning better nutrition? Were they redeeming the vouchers they received? Was it helping them reduce their blood pressure or blood sugar levels?

Prescription: fresh fruits and veggies

For seven months, the researchers followed participants who were at least 18 years old with a diagnosis of Type 2 diabetes that met certain clinical criteria. Doctors gave participants vouchers that could be redeemed for produce from certain vendors at three farmers markets in downtown Reading — one at the Farm Stand at the Downtown Campus, another at the Penn Street Market and the last at the Boscov’s Fairgrounds Farmers Market.

The participants — a significant portion of them Hispanic and Latino — received an initial set of produce vouchers — valued at two dollars each — and received more when they showed up for diabetes self-management education sessions. The classes, led by a dietitian and translated into Spanish by a community health worker, covered topics ranging from food preparation and nutrition to physical exercise.

“Hispanic and Latino individuals are more likely to be economically disadvantaged and have diabetes,” Veldheer said. “When you combine those factors, they’re at high risk because they may not be able to afford the optimal nutrition they need to manage their condition.”

Measuring success

At the beginning and end of the seven-month period, the researchers measured patients’ nutrition knowledge, body mass index, blood pressure and hemoglobin A1c — a blood test that measures average blood sugar levels over the past three months. The research team published the results of their study in the Journal of Nutrition Education and Behavior.

Between July 2018 and December 2019, more than 22,500 vouchers were redeemed, equaling more than $45,000 in produce being purchased from Reading area retailers and vendors. Approximately 78% of the distributed vouchers were redeemed for fresh fruits and vegetables.

“That’s a high redemption rate compared to what other similar studies have reported,” Weaver said.

“We also found that voucher redemption was significantly related to a decrease in A1c, which suggests that the vouchers paired with nutrition education helped some patients better manage their diabetes while participating,” Veldheer added.

A future of food as medicine

The research team has big plans for Veggie Rx. They’re converting to a hybrid in-person and virtual format for participants in light of the COVID-19 pandemic and hope to improve their data collection to continue evaluating whether the vouchers and diabetes self-management sessions are helping participants improve their health. They have also applied for funding from the National Institutes of Health (NIH) to conduct a clinical trial on the program. By designing a study that accounts for other factors like attendance at nutrition education sessions, differences in voucher redemption rates and changes in medication, the researchers hope to better measure Veggie Rx’s role in patients’ health.

“This project supports the NIH’s strategic plan for nutrition research, which seeks to improve existing evidence on the benefits of food-as-medicine programs in clinical settings,” Veldheer said. “It also fits into the College of Medicine’s strategic plan, which emphasizes research into new ways to manage chronic illnesses and address health disparities.”

“Food access and food insecurity is a worry for many residents in Reading,” Weaver said. “We hope that by providing easier access to fresh, nutritious produce it will lead to lifestyle changes and better health. We’re thrilled with the results to date and look forward to continuing our strategic community partnerships needed to sustain the program long-term.”

Christina Scartozzi, Candace Bordner, Diana Rodriguez, Arthur Berg and Christopher Sciamanna of Penn State College of Medicine; Chinwendu Opara of WellSpan Medical Group; and Brittany Williams of Lehigh Valley Health Network also contributed to this research.

This research was supported by the United Way of Berks County; The Centers for Disease Control and Prevention, Racial and Ethnic Approaches to Community Health (REACH) program (award number #6 NU 58DP 006587-01-01); the Penn State Leaman Endowment Research Award; and Penn State College of Medicine’s Department of Family and Community Medicine. The authors declare no conflicts of interest.

We want to thank the writer of this article for this amazing web content

Proof in produce: Voucher program may help diabetes patients manage their health

" ["date_timestamp"]=> int(1635712775) } [5]=> array(11) { ["title"]=> string(94) "The fascinating dances of microtubules, both skeletons of our cells and highways for molecules" ["link"]=> string(113) "https://bofads.com/the-fascinating-dances-of-microtubules-both-skeletons-of-our-cells-and-highways-for-molecules/" ["dc"]=> array(1) { ["creator"]=> string(12) "Paula Hooper" } ["pubdate"]=> string(31) "Sun, 31 Oct 2021 20:22:42 +0000" ["category"]=> string(68) "Sciencescellsdancesfascinatinghighwaysmicrotubulesmoleculesskeletons" ["guid"]=> string(26) "https://bofads.com/?p=1238" ["description"]=> string(694) "The microtubules are in blue, the dyneins, which are the molecular motors, are in red, and the DNA of the nucleus is in yellow. ALEXANDRE SCHAEFFER / CEA, SAINT LOUIS HOSPITAL “No one had ever seen this. We didn’t believe it ourselves. “ Here is what two French teams said to each other, without prior ... Read more" ["content"]=> array(1) { ["encoded"]=> string(4605) "

“No one had ever seen this. We didn’t believe it ourselves. “ Here is what two French teams said to each other, without prior consultation, after the discovery of surprising phenomena at the heart of cell life.

The two groups are studying the same object with puzzling properties: microtubules. These are long tubes (tens of micrometers) thin (25 nanometers in diameter), small “spaghetti” which act as a skeleton for the cells, but also highways for the transport of various molecules within them. All in constant agitation, made up of movements, creations, destruction … The best known of these tubes guide nerve signals along the axons of neurons or else cause numerous cilia or flagella to oscillate, like those of the tail of spermatozoa.

Read also: Article reserved for our subscribers Fifty years ago, tubulin changed cell biology …

The first team (Institut Curie, Cochin Hospital, Max-Planck Institute in Dresden and University of Bonn, Germany) took an interest in this beating appendage, of which a malfunction of the machinery is the cause of infertility.

Analogue au paquito

A flagellum moves and waves, thanks to the microtubules, which themselves oscillate thanks to a technique analogous to the Basque sport of paquito, where the participants sitting in single file make one of their team members advance, lying on their raised arms. It takes strength and synchronization. Ditto for the flagellum. Molecular motors, called dyneins, have one end hooked tightly to a first layer of microtubules, while their other ends, the “arms”, can catch or break off with a second layer of microtubules around the first. By pushing and pulling regularly, the assembly of dyneins undulates the upper and creates the flutter of the tail of the sperm, which thus runs straight towards the eggs.

Unless the microtubules are very slightly disturbed, as the researchers explain to the “one” of Science January 8. By genetically modifying mice, they prevented the arrival of only a few sweet amino acids, glycines, on the surface of microtubules, without interfering with the life of mammals. “We almost gave up because this change seemed to have no effect. Even the sperm appeared to be normal ”, recalls Carsten Janke, research director at CNRS and head of this team. By better studying the behavior of gametes, they nevertheless discovered that some no longer move in a straight line but go in circles. “We had to dive down to the molecular level to understand how a modification, a priori non-essential, could have such physiological consequences”, explains Carsten Janke.

You have 49.15% of this article to read. The rest is for subscribers only.

We want to say thanks to the author of this write-up for this remarkable material

The fascinating dances of microtubules, both skeletons of our cells and highways for molecules

" } ["summary"]=> string(694) "The microtubules are in blue, the dyneins, which are the molecular motors, are in red, and the DNA of the nucleus is in yellow. ALEXANDRE SCHAEFFER / CEA, SAINT LOUIS HOSPITAL “No one had ever seen this. We didn’t believe it ourselves. “ Here is what two French teams said to each other, without prior ... Read more" ["atom_content"]=> string(4605) "

“No one had ever seen this. We didn’t believe it ourselves. “ Here is what two French teams said to each other, without prior consultation, after the discovery of surprising phenomena at the heart of cell life.

The two groups are studying the same object with puzzling properties: microtubules. These are long tubes (tens of micrometers) thin (25 nanometers in diameter), small “spaghetti” which act as a skeleton for the cells, but also highways for the transport of various molecules within them. All in constant agitation, made up of movements, creations, destruction … The best known of these tubes guide nerve signals along the axons of neurons or else cause numerous cilia or flagella to oscillate, like those of the tail of spermatozoa.

Read also: Article reserved for our subscribers Fifty years ago, tubulin changed cell biology …

The first team (Institut Curie, Cochin Hospital, Max-Planck Institute in Dresden and University of Bonn, Germany) took an interest in this beating appendage, of which a malfunction of the machinery is the cause of infertility.

Analogue au paquito

A flagellum moves and waves, thanks to the microtubules, which themselves oscillate thanks to a technique analogous to the Basque sport of paquito, where the participants sitting in single file make one of their team members advance, lying on their raised arms. It takes strength and synchronization. Ditto for the flagellum. Molecular motors, called dyneins, have one end hooked tightly to a first layer of microtubules, while their other ends, the “arms”, can catch or break off with a second layer of microtubules around the first. By pushing and pulling regularly, the assembly of dyneins undulates the upper and creates the flutter of the tail of the sperm, which thus runs straight towards the eggs.

Unless the microtubules are very slightly disturbed, as the researchers explain to the “one” of Science January 8. By genetically modifying mice, they prevented the arrival of only a few sweet amino acids, glycines, on the surface of microtubules, without interfering with the life of mammals. “We almost gave up because this change seemed to have no effect. Even the sperm appeared to be normal ”, recalls Carsten Janke, research director at CNRS and head of this team. By better studying the behavior of gametes, they nevertheless discovered that some no longer move in a straight line but go in circles. “We had to dive down to the molecular level to understand how a modification, a priori non-essential, could have such physiological consequences”, explains Carsten Janke.

You have 49.15% of this article to read. The rest is for subscribers only.

We want to say thanks to the author of this write-up for this remarkable material

The fascinating dances of microtubules, both skeletons of our cells and highways for molecules

" ["date_timestamp"]=> int(1635711762) } [6]=> array(11) { ["title"]=> string(52) "Apple unveils improved iPad Pro with M1 power source" ["link"]=> string(72) "https://bofads.com/apple-unveils-improved-ipad-pro-with-m1-power-source/" ["dc"]=> array(1) { ["creator"]=> string(11) "David Lonit" } ["pubdate"]=> string(31) "Sun, 31 Oct 2021 20:17:54 +0000" ["category"]=> string(45) "GadgetsAppleimprovediPadpowerProsourceUnveils" ["guid"]=> string(26) "https://bofads.com/?p=1235" ["description"]=> string(574) "The iPad Pro, the top model from Apple’s tablet series, will receive a major upgrade next month. For example, the device is equipped with the M1 chip that also powers the latest computers from Apple, a so-called XDR display with more than ten thousand mini-LEDs and 5G technology. It comes as no surprise to anyone ... Read more" ["content"]=> array(1) { ["encoded"]=> string(5475) "

The iPad Pro, the top model from Apple’s tablet series, will receive a major upgrade next month. For example, the device is equipped with the M1 chip that also powers the latest computers from Apple, a so-called XDR display with more than ten thousand mini-LEDs and 5G technology.

It comes as no surprise to anyone that Apple was going to replace the Intel processors in its notebooks and laptops with its own M1 Silicon power source as soon as possible. Since this week, the iMac also has the SoC (System-On-a-Chip) based on ARM technology. But that the iPad Pro would also be replaced by an M1 in no time gepowered (formerly an A12Z Bionic processor), we didn’t see that coming right away.

Faster, more economical

It is an M1 with 8-core CPU, 8-core GPU and a 16-core Neural Engine. According to Apple, the CPU works up to fifty percent faster, the GPU in turn provides forty percent faster graphics. And because the M1 is more energy efficient than the iPad’s previous powerplant, the tablet’s battery should still last a full day.

Blinker number two is the 12.9-inch Liquid Retina XDR screen of the (most expensive) iPad Pro. That contains no less than ten thousand mini-LEDs, which guarantee a full-screen brightness of 1,000 nits, a peak brightness of 1,600 nits and a contrast ratio of 1,000,000:1. In addition, the display supports advanced technology such as Wide Color Rendering (P3), True Tone and ProMotion (with an adaptive refresh rate of 120 Hz).

With the also new 11-inch version of the iPad Pro, the peak brightness is 600 nits. True Tone, ProMotion and P3 are not missing on this model either.

5G and Wifi 6

As always, you can opt for a WiFi-only version with the iPad, or for a model that also offers mobile data. With the new iPad Pro, this is 5G connectivity for the first time. Indoors, the user can benefit from a fast Wifi 6 connection.

Other specs include the 12MP ultra-wide-angle front camera (which can track users when they leave their seat, for example, during a meeting, and also offers Face ID unlocking), and a Pro rear camera system consisting of two 10 sensors. and 12 megapixels. A LiDAR scanner, already added to the iPad Pro of 2020 in March last year, completes the picture.

Prices and availability

The iPad Pro will be available in mid-May in an 11-inch version with Liquid Retina display, and a 12.9-inch version with Liquid Retina XDR display. Prices start at 899 euros and go up to 2,599 euros for the absolute top version, including 2 TB storage space and 5G.

It comes as no surprise to anyone that Apple was going to replace the Intel processors in its notebooks and laptops with its own M1 Silicon power source as soon as possible. Since this week, the iMac also has the SoC (System-On-a-Chip) based on ARM technology. But we didn’t immediately see that the iPad Pro would also be powered by an M1 (formerly an A12Z Bionic processor) in no time. It concerns an M1 with an 8-core CPU, 8-core GPU and a 16 -core neural engine. According to Apple, the CPU works up to fifty percent faster, the GPU in turn provides forty percent faster graphics. And because the M1 is more energy efficient than the iPad’s previous powerplant, the tablet’s battery should still last a full day. The number two flasher is the 12.9-inch Liquid Retina XDR display on the (most expensive) iPad Pro. That contains no less than ten thousand mini-LEDs, which guarantee a full-screen brightness of 1,000 nits, a peak brightness of 1,600 nits and a contrast ratio of 1,000,000:1. In addition, the display supports advanced technology such as wide color reproduction (P3), True Tone and ProMotion (with an adaptive refresh rate of 120 Hz). With the also new 11-inch version of the iPad Pro, the peak brightness is 600 nits. True Tone, ProMotion and P3 are not missing on this model either. As always, you can opt for a WiFi-only version with the iPad, or for a model that also offers mobile data. With the new iPad Pro, this is 5G connectivity for the first time. Indoors, the user can take advantage of a fast Wifi 6 connection. Other specs include the 12 MP ultra-wide-angle front camera (which can track users when they leave their place during a meeting, for example, and also offers Face ID unlocking), and a Pro rear camera system consisting of two 10 and 12 megapixel sensors. A LiDAR scanner, already added to the iPad Pro of 2020 in March of last year, completes the picture. The iPad Pro will be available from mid-May in an 11-inch version with Liquid Retina display, and a 12.9-inch version with Liquid Retina XDR display. Prices start at 899 euros and go up to 2,599 euros for the absolute top version, including 2 TB storage space and 5G.

We would like to give thanks to the writer of this article for this amazing content

Apple unveils improved iPad Pro with M1 power source

" } ["summary"]=> string(574) "The iPad Pro, the top model from Apple’s tablet series, will receive a major upgrade next month. For example, the device is equipped with the M1 chip that also powers the latest computers from Apple, a so-called XDR display with more than ten thousand mini-LEDs and 5G technology. It comes as no surprise to anyone ... Read more" ["atom_content"]=> string(5475) "

The iPad Pro, the top model from Apple’s tablet series, will receive a major upgrade next month. For example, the device is equipped with the M1 chip that also powers the latest computers from Apple, a so-called XDR display with more than ten thousand mini-LEDs and 5G technology.

It comes as no surprise to anyone that Apple was going to replace the Intel processors in its notebooks and laptops with its own M1 Silicon power source as soon as possible. Since this week, the iMac also has the SoC (System-On-a-Chip) based on ARM technology. But that the iPad Pro would also be replaced by an M1 in no time gepowered (formerly an A12Z Bionic processor), we didn’t see that coming right away.

Faster, more economical

It is an M1 with 8-core CPU, 8-core GPU and a 16-core Neural Engine. According to Apple, the CPU works up to fifty percent faster, the GPU in turn provides forty percent faster graphics. And because the M1 is more energy efficient than the iPad’s previous powerplant, the tablet’s battery should still last a full day.

Blinker number two is the 12.9-inch Liquid Retina XDR screen of the (most expensive) iPad Pro. That contains no less than ten thousand mini-LEDs, which guarantee a full-screen brightness of 1,000 nits, a peak brightness of 1,600 nits and a contrast ratio of 1,000,000:1. In addition, the display supports advanced technology such as Wide Color Rendering (P3), True Tone and ProMotion (with an adaptive refresh rate of 120 Hz).

With the also new 11-inch version of the iPad Pro, the peak brightness is 600 nits. True Tone, ProMotion and P3 are not missing on this model either.

5G and Wifi 6

As always, you can opt for a WiFi-only version with the iPad, or for a model that also offers mobile data. With the new iPad Pro, this is 5G connectivity for the first time. Indoors, the user can benefit from a fast Wifi 6 connection.

Other specs include the 12MP ultra-wide-angle front camera (which can track users when they leave their seat, for example, during a meeting, and also offers Face ID unlocking), and a Pro rear camera system consisting of two 10 sensors. and 12 megapixels. A LiDAR scanner, already added to the iPad Pro of 2020 in March last year, completes the picture.

Prices and availability

The iPad Pro will be available in mid-May in an 11-inch version with Liquid Retina display, and a 12.9-inch version with Liquid Retina XDR display. Prices start at 899 euros and go up to 2,599 euros for the absolute top version, including 2 TB storage space and 5G.

It comes as no surprise to anyone that Apple was going to replace the Intel processors in its notebooks and laptops with its own M1 Silicon power source as soon as possible. Since this week, the iMac also has the SoC (System-On-a-Chip) based on ARM technology. But we didn’t immediately see that the iPad Pro would also be powered by an M1 (formerly an A12Z Bionic processor) in no time. It concerns an M1 with an 8-core CPU, 8-core GPU and a 16 -core neural engine. According to Apple, the CPU works up to fifty percent faster, the GPU in turn provides forty percent faster graphics. And because the M1 is more energy efficient than the iPad’s previous powerplant, the tablet’s battery should still last a full day. The number two flasher is the 12.9-inch Liquid Retina XDR display on the (most expensive) iPad Pro. That contains no less than ten thousand mini-LEDs, which guarantee a full-screen brightness of 1,000 nits, a peak brightness of 1,600 nits and a contrast ratio of 1,000,000:1. In addition, the display supports advanced technology such as wide color reproduction (P3), True Tone and ProMotion (with an adaptive refresh rate of 120 Hz). With the also new 11-inch version of the iPad Pro, the peak brightness is 600 nits. True Tone, ProMotion and P3 are not missing on this model either. As always, you can opt for a WiFi-only version with the iPad, or for a model that also offers mobile data. With the new iPad Pro, this is 5G connectivity for the first time. Indoors, the user can take advantage of a fast Wifi 6 connection. Other specs include the 12 MP ultra-wide-angle front camera (which can track users when they leave their place during a meeting, for example, and also offers Face ID unlocking), and a Pro rear camera system consisting of two 10 and 12 megapixel sensors. A LiDAR scanner, already added to the iPad Pro of 2020 in March of last year, completes the picture. The iPad Pro will be available from mid-May in an 11-inch version with Liquid Retina display, and a 12.9-inch version with Liquid Retina XDR display. Prices start at 899 euros and go up to 2,599 euros for the absolute top version, including 2 TB storage space and 5G.

We would like to give thanks to the writer of this article for this amazing content

Apple unveils improved iPad Pro with M1 power source

" ["date_timestamp"]=> int(1635711474) } [7]=> array(11) { ["title"]=> string(103) "Slavia – Plzeň 2: 0, Plzeň finished in Eden without three eliminated, so Slavia finally defeated it" ["link"]=> string(114) "https://bofads.com/slavia-plzen-2-0-plzen-finished-in-eden-without-three-eliminated-so-slavia-finally-defeated-it/" ["dc"]=> array(1) { ["creator"]=> string(8) "Tim Hall" } ["pubdate"]=> string(31) "Sun, 31 Oct 2021 20:03:47 +0000" ["category"]=> string(54) "SportdefeatedEdeneliminatedfinallyfinishedPlzeňSlavia" ["guid"]=> string(26) "https://bofads.com/?p=1232" ["description"]=> string(715) "Radim Řezník in a discussion with the referee. Vlastimil Vacek, Right After a dozen minutes, it was clear that there would be nothing from the league hit. Or that there would be little left of him, because after the expulsion of Řezník it was evident that Plzeň would defend at ten, save minutes and wait ... Read more" ["content"]=> array(1) { ["encoded"]=> string(6163) "

Vlastimil Vacek, Right

After a dozen minutes, it was clear that there would be nothing from the league hit. Or that there would be little left of him, because after the expulsion of Řezník it was evident that Plzeň would defend at ten, save minutes and wait to see if it would still offer an opportunity to endanger Mandous’s gate. What else to expect from her in a duel in which she cared a lot, as well as the home Slavia ?!

At the same time, after Řezník’s intervention on Ševčík, Judge Franěk was at first satisfied only with the warning addressed to the visiting defender. It wasn’t until his colleague in the video Štěrba appealed that he should draw a red card and the main one gave it to him after examining the video.

The butcher really overdid it and forced Victoria to play for more than 80 minutes in weakness.

Radim Řezník saw a red card right at the beginning of the match with Slavia.

Vlastimil Vacek, Right

However, the homeowners, to whose team the healed Carnival returned and in which Olayinka also injured in Wednesday’s finish with Olomouc, came out, the numerical superiority was useless. For the whole first half, they did not create a more serious chance, let alone to send a good shot at Staňek. Their territorial superiority steadily failed on the formed defense of the opponent. All events were too lengthy, complicated and legible. There was no acceleration, no moment of surprise, no idea, and most importantly no emphasis in the penalty area, so he stayed at the goalless score.

Coach Trpišovský reacted by half with two line-up changes, but the guests scored their first dangerous shooting attempt in the match. Bucha’s shot from the standard situation was very unpleasant for Mandous, but the new goalkeeper number one, Slavia, boxed it out.

Jan Kopic from Viktoria Plzeň and Ondřej Lingr from Slavia Prague

Vlastimil Vacek, Right

And when, a few minutes later, Franek decided that Ekpaia’s foul on the Mosque was not one of those who would call for a second yellow and therefore expulsion, Slavia could resume the siege of sixteen guests.

Already more emphatic and stronger than before the break, and after 65 minutes with a crowned goal by Lingra, who, however, explored the video for a good three minutes. In the end, however, this told the judge that it was not an offside after Stanciu’s long-range shot, which Staněk did not keep.

Ondřej Lingr from Slavia Prague celebrates his goal with his teammates at 1: 0

Vlastimil Vacek, Right

Pilsen was thus forced to think about the attack after the collected goal, but after a few sporadic attempts, it fell short of its intention. In the 81st minute, Pernica was eliminated after the intervention on Plavšič, in the first set minute he was followed by Mosquera.

The guests finished only in eight men, so in the fifth set minute Krmenčík punished them with the second goal. The very first goal, which he scored in a stitched jersey from the game and which only underlined the account of the unsuccessful hit.

Slavia Praha – Viktoria Plzen 2: 0 (0: 0)
Goal: 65. Lingr <90. + 5 Krmenčík .. Referee: Franek – Caletka, Kriz – Sterba (video). ČK: 11. Butcher, 82. Pernica, 90. + 1 Mosquera (Pilsen). ŽK: Ekpai – Kalvach, Mosquera. Viewers: 18 179.
Slavia: Mandous – Bah (46. Samek), Ousou, Kačaraba, Masopust – Hromada (46. Stanciu), Ševčík – Ekpai (59. Plavšič), Lingr (79. Traoré), Olayinka – Kucht (59. Krmenčík). Coach: Trpišovský.
Pilsen: Staněk – Řezník, Pernica, Hejda, Havel – Kalvach (87. Chorý), Bucha – Kopic (77. Šulc), Sýkora (82. Kaša), Mosquera – Beauguel. Coach: Bílek.

We would love to say thanks to the writer of this write-up for this awesome web content

Slavia – Plzeň 2: 0, Plzeň finished in Eden without three eliminated, so Slavia finally defeated it

" } ["summary"]=> string(715) "Radim Řezník in a discussion with the referee. Vlastimil Vacek, Right After a dozen minutes, it was clear that there would be nothing from the league hit. Or that there would be little left of him, because after the expulsion of Řezník it was evident that Plzeň would defend at ten, save minutes and wait ... Read more" ["atom_content"]=> string(6163) "

Vlastimil Vacek, Right

After a dozen minutes, it was clear that there would be nothing from the league hit. Or that there would be little left of him, because after the expulsion of Řezník it was evident that Plzeň would defend at ten, save minutes and wait to see if it would still offer an opportunity to endanger Mandous’s gate. What else to expect from her in a duel in which she cared a lot, as well as the home Slavia ?!

At the same time, after Řezník’s intervention on Ševčík, Judge Franěk was at first satisfied only with the warning addressed to the visiting defender. It wasn’t until his colleague in the video Štěrba appealed that he should draw a red card and the main one gave it to him after examining the video.

The butcher really overdid it and forced Victoria to play for more than 80 minutes in weakness.

Radim Řezník saw a red card right at the beginning of the match with Slavia.

Vlastimil Vacek, Right

However, the homeowners, to whose team the healed Carnival returned and in which Olayinka also injured in Wednesday’s finish with Olomouc, came out, the numerical superiority was useless. For the whole first half, they did not create a more serious chance, let alone to send a good shot at Staňek. Their territorial superiority steadily failed on the formed defense of the opponent. All events were too lengthy, complicated and legible. There was no acceleration, no moment of surprise, no idea, and most importantly no emphasis in the penalty area, so he stayed at the goalless score.

Coach Trpišovský reacted by half with two line-up changes, but the guests scored their first dangerous shooting attempt in the match. Bucha’s shot from the standard situation was very unpleasant for Mandous, but the new goalkeeper number one, Slavia, boxed it out.

Jan Kopic from Viktoria Plzeň and Ondřej Lingr from Slavia Prague

Vlastimil Vacek, Right

And when, a few minutes later, Franek decided that Ekpaia’s foul on the Mosque was not one of those who would call for a second yellow and therefore expulsion, Slavia could resume the siege of sixteen guests.

Already more emphatic and stronger than before the break, and after 65 minutes with a crowned goal by Lingra, who, however, explored the video for a good three minutes. In the end, however, this told the judge that it was not an offside after Stanciu’s long-range shot, which Staněk did not keep.

Ondřej Lingr from Slavia Prague celebrates his goal with his teammates at 1: 0

Vlastimil Vacek, Right

Pilsen was thus forced to think about the attack after the collected goal, but after a few sporadic attempts, it fell short of its intention. In the 81st minute, Pernica was eliminated after the intervention on Plavšič, in the first set minute he was followed by Mosquera.

The guests finished only in eight men, so in the fifth set minute Krmenčík punished them with the second goal. The very first goal, which he scored in a stitched jersey from the game and which only underlined the account of the unsuccessful hit.

Slavia Praha – Viktoria Plzen 2: 0 (0: 0)
Goal: 65. Lingr <90. + 5 Krmenčík .. Referee: Franek – Caletka, Kriz – Sterba (video). ČK: 11. Butcher, 82. Pernica, 90. + 1 Mosquera (Pilsen). ŽK: Ekpai – Kalvach, Mosquera. Viewers: 18 179.
Slavia: Mandous – Bah (46. Samek), Ousou, Kačaraba, Masopust – Hromada (46. Stanciu), Ševčík – Ekpai (59. Plavšič), Lingr (79. Traoré), Olayinka – Kucht (59. Krmenčík). Coach: Trpišovský.
Pilsen: Staněk – Řezník, Pernica, Hejda, Havel – Kalvach (87. Chorý), Bucha – Kopic (77. Šulc), Sýkora (82. Kaša), Mosquera – Beauguel. Coach: Bílek.

We would love to say thanks to the writer of this write-up for this awesome web content

Slavia – Plzeň 2: 0, Plzeň finished in Eden without three eliminated, so Slavia finally defeated it

" ["date_timestamp"]=> int(1635710627) } [8]=> array(11) { ["title"]=> string(57) "Concerts, shows and fervo this weekend. check it out now" ["link"]=> string(74) "https://bofads.com/concerts-shows-and-fervo-this-weekend-check-it-out-now/" ["dc"]=> array(1) { ["creator"]=> string(12) "Paula Hooper" } ["pubdate"]=> string(31) "Sun, 31 Oct 2021 20:01:08 +0000" ["category"]=> string(30) "MusiccheckConcertsfervoWeekend" ["guid"]=> string(26) "https://bofads.com/?p=1229" ["description"]=> string(556) "short Music Non Stop no Facebook Weekend!! We can’t stand it and we start saying that today, from 8 pm we, from Music Non Stop, are going to invade Jerome – one of the most loved clubs in São Paulo – with DJing by muse Claudia Assef, muse Jota Wagner and, direct from Floripa, DJ ... Read more" ["content"]=> array(1) { ["encoded"]=> string(24787) "

Weekend!! We can’t stand it and we start saying that today, from 8 pm we, from Music Non Stop, are going to invade Jerome – one of the most loved clubs in São Paulo – with DJing by muse Claudia Assef, muse Jota Wagner and, direct from Floripa, DJ Lycra Preta who, in addition to enchanting the island with his house music sets, also collaborates with us sending praised articles. Then later we have an appointment at Mato Grosso, 398 – Consolação (Entrance, $20). And, as the weekend is just beginning, between Saturday and Sunday there are also concerts, exhibitions, tours and film shows.

Music Non Stop no Jerome

Friday, October 8th from 8pm to 2am.
Admission, $ 20
Jerome is located at Rua Mato Grosso, 398 – Consolação.
Reservations: 11 9 99540477

music non stop sessions no jerome

Ibira

From this Friday, October 8th, the Ibirapuera Planetarium will feature two shows: From Earth to Universe and Scientific Project. The show will be in fulldome projection, immersive video display technology, with dynamic projection throughout the dome. Each session is approximately 35 minutes and is recommended for audiences over 5 years old. Tickets cost between R 15.00 and R﹩ 30.00 and can be purchased on the website https://www.ibirapueraparque.com.br/ .

In addition, to celebrate Children’s Day, the Planetarium will also have a children’s show starting this Friday, at 1 pm. It will be 35 minutes long and, although it is a children’s session, it is free for all ages. The broadcast will bring the story of Neco and Silo, two pre-teen characters living on the planet Assilar, who have just won a school award for a scientific project on the Solar System. Youthful satisfaction turns into excitement and, at night, hidden from their parents, they make a pirate broadcast to publicize the feat. Admission is free, with booking through the same website. It is noteworthy that visitors must bring warm clothes, as the room has air conditioning. The space is open 30 minutes before each attraction and ENTRY IS NOT ALLOWED AFTER THE SESSION STARTS!

Night at the Planetarium at Ibirapuera Park, in São Paulo | Disclosure: Urbia Parks

Biennial

For those who want to check out the 34th Bienal de São Paulo: It’s dark but I sing, the available times are on Tuesdays, Wednesdays, Fridays and Sundays, from 10 am to 7 pm, and on Thursdays and Saturdays, from 10 am to 9 pm. Admission is free, and it is possible to book a date in Visit Scheduling .

Visitors to the 34th Bienal de São Paulo will be able to visit the new gastronomic space organized in the external area of ​​the pavilion. Developed in partnership between Urbia and the Bienal, the space has food trucks, which offer pastries, sandwiches and ice cream, and will operate from Tuesday to Thursday, from 10 am to 7 pm, in addition to Fridays to Sundays and holidays, from 10 am to 9 pm, and it brings the Tetto Y Aragon restaurant, specialized in Hispanic cuisine, which will be open from Tuesday to Thursday, from 12:00 to 19:00, and from Friday to Sunday and holidays, from 12:00 to 21:00.

Biennial Building SP

Photo: © Freddy Leal / São Paulo Biennial Foundation

I HAVE

The Museum of Modern Art (MAM) is open with free entry from Tuesday to Sunday, from 10:00 am to 6:00 pm (admission until 5:30 pm). With a suggested contribution, the visitor will be able to choose if they prefer to enter for free or if they want to contribute with some value. This format runs until December 12, 2021 and tickets can be purchased by appointment via the website. I HAVE . The Afro Brasil Museum is open from 11:00 am to 4:00 pm (with stay until 5:00 pm) and admission costs R﹩15 (full) and R﹩7.50 (half). To purchase tickets you need to access the page Afro Brazil Museum .

Modern Art Museum. Photo disclosure/MAM

Japanese Pavilion

After two years closed to the public because of the pandemic, the Japanese Pavilion reopened its doors with the opening of exhibition Bonsai – Form and Time, in the garden that surrounds its installations, with around 100 rare pieces of more than 40 species of different trees. The exhibition brings the challenge of illustrating, with thematic and formal frameworks, the delicate and powerful universe of reduced trees. The attraction opened on September 25th and will be on display until November 21st this year.

Japanese pavilion. Photo disclosure

Guided Tour – IbiraTour

Ibirapuera’s attendees have gained another leisure option and can now take a tour of the Park on a circuit with electric carts. The guided tour is a project developed by Urbia and aims to present the Park in a 45-minute journey. Carts with capacity for up to four people at a time will be made available on a circuit without breaks or descents during the journey, covering all areas of the Park. The service takes place from Monday to Friday, from 10 am to 6 pm, and the value of the tour is R﹩25, with payment options in cash, credit and debit. The embarkation and disembarkation point is at Gate 4.

online programming

Shown since March directly from the Ibirapuera Auditorium, Saia Justa this Wednesday, October 6th, will feature the participation of the actress Kefera Buchmann. The Auditorium was specially adapted for the broadcast of the program, with the seats of the audience composing part of the scenario. The program is broadcast on the GNT channel and has a presentation by Astrid Fontenelle, Mônica Martelli, Pitty e Gaby Amarantos.

Concertos

On Sunday, October 10th, the Heliópolis Symphony Orchestra get on the stage of Ibirapuera Auditorium, from 17h. The live presentation will be in celebration of the 25th anniversary of the Baccarelli Institute, and can be seen on the official YouTube channel of Ibirapuera park, on here. The event is part of the Concert Season 2021 of the Baccarelli Institute.

Heliópolis Symphony Orchestra. Priscilla Corderi’s photo

CCSP

On October 23rd and 24th, the Profane Collective leads to São Paulo Cultural Center Ritu.1/ Penetrates! This is the first performative action in the series of trans-i- rituals.[ação] that the actress, director, playwright and doctoral student at USP Manfrin has been working out in parallel to your hormonal transition process. At the invitation of the CCSP In this resumption of cultural activities in this important space for Contemporary Art, Manfrin brings an exploration of Time in its hormonal transition process through an extremely visceral long-term performance.

Part 01 of a trans-i- ritual[ação]!
Duration: 06 hours
Spaces used: First floor entrance ramp from 4 pm to 8 pm
Flávio de Carvalho Floor Exhibition Room from 8:30 pm to 10:00 pm

Service:
Saturday, 10/23 – from 4:00 pm to 10:00 pm
Sunday, 10/24 – from 3:00 pm to 9:00 pm
Free

Photo: Julio Aracack

theater

the tale Tarlatana Rosa’s Baby, from João do Rio, is the guiding line of the homonymous show of Queen Kong, which is scheduled to premiere on October 22, on Arthur Azevedo Theater. The season, which runs until 11/14, will take place online and without an audience and will cover three other stages in the city: Alfredo Mesquita Theater, Cacilda Becker Theater and João Caetano Theater, all belonging to the public apparatus of São Paulo culture. Casa 1, the LGBT+ culture and welcome center, will also receive shows at the end of the season. The presentations are part of the project As Histórias de Baixo, which was included in the 36th edition of the Municipal Theater Promotion Program to the City of São Paulo.

Friday and Saturday at 9 pm and Sunday at 7 pm
Free – online
Duration: 50 minutes

The shows will be broadcast directly from the stages:

THEATER ARTHUR AZEVEDO
October 22, 23 and 24, 2021

THEATER ALFREDO MOSQUE
Days: October 29, 30 and 31, 2021

CACILDA BECKER THEATER

Days: November 5th, 6th and 7th, 2021

THEATER JOÃO CAETANO

Days: 12, 13 and 14 November 2021

HOME 1

Days: November 19, 20 and 21, 2021

Tarlatana Rosa's Baby.

Tarlatana Rosa’s Baby. Photo: Karen Mezza

Women’s Film Show

O Juquery Women’s Basin Collective, by Franco da Rocha, performs the VI edition of the Women’s Film Festival, until October 10, 2021. The tour continues this weekend with virtual exhibitions, through the Youtube.

October 8th – Public policies for women
Online exhibitions 24 hours a day through the YouTube, and debate at 7pm.
Film debater: Pamela Gabrielle

Films:
from the house to life
(In)visible girls
Lora

October 9th – Women and the breaking of traditional
Online exhibitions 24 hours a day through the YouTube, and debate at 7pm.
Film debater: Vita Pereira

Films
grout
women of faith
Babi & Elvis

October 10th – Free Theme
Online exhibitions through the channel YouTube 24h a day

Films
Far right troll
house with wall
The only thing I understand as north is freedom.

cinema workshop

SESC Digital – African Film Show

Until October 10th, 30 contemporary film titles are screened, most of them unpublished in the national territory, which address a little of contemporary African cinematographic production, through Sesc Digital platform. Everyone is available throughout the entire festival, except Gagarine Building, online for 24 hours, and you will die at twenty, with a limit of 500 views.

Short “Al-Sit”, by Suzannah Mirghani, is part of the show’s program. Credit: Doha Film Institute/African Film Festival Press Office

Amanda Sousa

Amanda Sousa is a mother, a feminist, is 30 years old and has a degree in Social Communication. Born in São Paulo, currently lives in Jundiaí. She is passionate about music since she understands people. He goes from punk to pop, he likes to discover sounds in all aspects.

We would like to give thanks to the author of this write-up for this incredible material

Concerts, shows and fervo this weekend. check it out now

" } ["summary"]=> string(556) "short Music Non Stop no Facebook Weekend!! We can’t stand it and we start saying that today, from 8 pm we, from Music Non Stop, are going to invade Jerome – one of the most loved clubs in São Paulo – with DJing by muse Claudia Assef, muse Jota Wagner and, direct from Floripa, DJ ... Read more" ["atom_content"]=> string(24787) "

Weekend!! We can’t stand it and we start saying that today, from 8 pm we, from Music Non Stop, are going to invade Jerome – one of the most loved clubs in São Paulo – with DJing by muse Claudia Assef, muse Jota Wagner and, direct from Floripa, DJ Lycra Preta who, in addition to enchanting the island with his house music sets, also collaborates with us sending praised articles. Then later we have an appointment at Mato Grosso, 398 – Consolação (Entrance, $20). And, as the weekend is just beginning, between Saturday and Sunday there are also concerts, exhibitions, tours and film shows.

Music Non Stop no Jerome

Friday, October 8th from 8pm to 2am.
Admission, $ 20
Jerome is located at Rua Mato Grosso, 398 – Consolação.
Reservations: 11 9 99540477

music non stop sessions no jerome

Ibira

From this Friday, October 8th, the Ibirapuera Planetarium will feature two shows: From Earth to Universe and Scientific Project. The show will be in fulldome projection, immersive video display technology, with dynamic projection throughout the dome. Each session is approximately 35 minutes and is recommended for audiences over 5 years old. Tickets cost between R 15.00 and R﹩ 30.00 and can be purchased on the website https://www.ibirapueraparque.com.br/ .

In addition, to celebrate Children’s Day, the Planetarium will also have a children’s show starting this Friday, at 1 pm. It will be 35 minutes long and, although it is a children’s session, it is free for all ages. The broadcast will bring the story of Neco and Silo, two pre-teen characters living on the planet Assilar, who have just won a school award for a scientific project on the Solar System. Youthful satisfaction turns into excitement and, at night, hidden from their parents, they make a pirate broadcast to publicize the feat. Admission is free, with booking through the same website. It is noteworthy that visitors must bring warm clothes, as the room has air conditioning. The space is open 30 minutes before each attraction and ENTRY IS NOT ALLOWED AFTER THE SESSION STARTS!

Night at the Planetarium at Ibirapuera Park, in São Paulo | Disclosure: Urbia Parks

Biennial

For those who want to check out the 34th Bienal de São Paulo: It’s dark but I sing, the available times are on Tuesdays, Wednesdays, Fridays and Sundays, from 10 am to 7 pm, and on Thursdays and Saturdays, from 10 am to 9 pm. Admission is free, and it is possible to book a date in Visit Scheduling .

Visitors to the 34th Bienal de São Paulo will be able to visit the new gastronomic space organized in the external area of ​​the pavilion. Developed in partnership between Urbia and the Bienal, the space has food trucks, which offer pastries, sandwiches and ice cream, and will operate from Tuesday to Thursday, from 10 am to 7 pm, in addition to Fridays to Sundays and holidays, from 10 am to 9 pm, and it brings the Tetto Y Aragon restaurant, specialized in Hispanic cuisine, which will be open from Tuesday to Thursday, from 12:00 to 19:00, and from Friday to Sunday and holidays, from 12:00 to 21:00.

Biennial Building SP

Photo: © Freddy Leal / São Paulo Biennial Foundation

I HAVE

The Museum of Modern Art (MAM) is open with free entry from Tuesday to Sunday, from 10:00 am to 6:00 pm (admission until 5:30 pm). With a suggested contribution, the visitor will be able to choose if they prefer to enter for free or if they want to contribute with some value. This format runs until December 12, 2021 and tickets can be purchased by appointment via the website. I HAVE . The Afro Brasil Museum is open from 11:00 am to 4:00 pm (with stay until 5:00 pm) and admission costs R﹩15 (full) and R﹩7.50 (half). To purchase tickets you need to access the page Afro Brazil Museum .

Modern Art Museum. Photo disclosure/MAM

Japanese Pavilion

After two years closed to the public because of the pandemic, the Japanese Pavilion reopened its doors with the opening of exhibition Bonsai – Form and Time, in the garden that surrounds its installations, with around 100 rare pieces of more than 40 species of different trees. The exhibition brings the challenge of illustrating, with thematic and formal frameworks, the delicate and powerful universe of reduced trees. The attraction opened on September 25th and will be on display until November 21st this year.

Japanese pavilion. Photo disclosure

Guided Tour – IbiraTour

Ibirapuera’s attendees have gained another leisure option and can now take a tour of the Park on a circuit with electric carts. The guided tour is a project developed by Urbia and aims to present the Park in a 45-minute journey. Carts with capacity for up to four people at a time will be made available on a circuit without breaks or descents during the journey, covering all areas of the Park. The service takes place from Monday to Friday, from 10 am to 6 pm, and the value of the tour is R﹩25, with payment options in cash, credit and debit. The embarkation and disembarkation point is at Gate 4.

online programming

Shown since March directly from the Ibirapuera Auditorium, Saia Justa this Wednesday, October 6th, will feature the participation of the actress Kefera Buchmann. The Auditorium was specially adapted for the broadcast of the program, with the seats of the audience composing part of the scenario. The program is broadcast on the GNT channel and has a presentation by Astrid Fontenelle, Mônica Martelli, Pitty e Gaby Amarantos.

Concertos

On Sunday, October 10th, the Heliópolis Symphony Orchestra get on the stage of Ibirapuera Auditorium, from 17h. The live presentation will be in celebration of the 25th anniversary of the Baccarelli Institute, and can be seen on the official YouTube channel of Ibirapuera park, on here. The event is part of the Concert Season 2021 of the Baccarelli Institute.

Heliópolis Symphony Orchestra. Priscilla Corderi’s photo

CCSP

On October 23rd and 24th, the Profane Collective leads to São Paulo Cultural Center Ritu.1/ Penetrates! This is the first performative action in the series of trans-i- rituals.[ação] that the actress, director, playwright and doctoral student at USP Manfrin has been working out in parallel to your hormonal transition process. At the invitation of the CCSP In this resumption of cultural activities in this important space for Contemporary Art, Manfrin brings an exploration of Time in its hormonal transition process through an extremely visceral long-term performance.

Part 01 of a trans-i- ritual[ação]!
Duration: 06 hours
Spaces used: First floor entrance ramp from 4 pm to 8 pm
Flávio de Carvalho Floor Exhibition Room from 8:30 pm to 10:00 pm

Service:
Saturday, 10/23 – from 4:00 pm to 10:00 pm
Sunday, 10/24 – from 3:00 pm to 9:00 pm
Free

Photo: Julio Aracack

theater

the tale Tarlatana Rosa’s Baby, from João do Rio, is the guiding line of the homonymous show of Queen Kong, which is scheduled to premiere on October 22, on Arthur Azevedo Theater. The season, which runs until 11/14, will take place online and without an audience and will cover three other stages in the city: Alfredo Mesquita Theater, Cacilda Becker Theater and João Caetano Theater, all belonging to the public apparatus of São Paulo culture. Casa 1, the LGBT+ culture and welcome center, will also receive shows at the end of the season. The presentations are part of the project As Histórias de Baixo, which was included in the 36th edition of the Municipal Theater Promotion Program to the City of São Paulo.

Friday and Saturday at 9 pm and Sunday at 7 pm
Free – online
Duration: 50 minutes

The shows will be broadcast directly from the stages:

THEATER ARTHUR AZEVEDO
October 22, 23 and 24, 2021

THEATER ALFREDO MOSQUE
Days: October 29, 30 and 31, 2021

CACILDA BECKER THEATER

Days: November 5th, 6th and 7th, 2021

THEATER JOÃO CAETANO

Days: 12, 13 and 14 November 2021

HOME 1

Days: November 19, 20 and 21, 2021

Tarlatana Rosa's Baby.

Tarlatana Rosa’s Baby. Photo: Karen Mezza

Women’s Film Show

O Juquery Women’s Basin Collective, by Franco da Rocha, performs the VI edition of the Women’s Film Festival, until October 10, 2021. The tour continues this weekend with virtual exhibitions, through the Youtube.

October 8th – Public policies for women
Online exhibitions 24 hours a day through the YouTube, and debate at 7pm.
Film debater: Pamela Gabrielle

Films:
from the house to life
(In)visible girls
Lora

October 9th – Women and the breaking of traditional
Online exhibitions 24 hours a day through the YouTube, and debate at 7pm.
Film debater: Vita Pereira

Films
grout
women of faith
Babi & Elvis

October 10th – Free Theme
Online exhibitions through the channel YouTube 24h a day

Films
Far right troll
house with wall
The only thing I understand as north is freedom.

cinema workshop

SESC Digital – African Film Show

Until October 10th, 30 contemporary film titles are screened, most of them unpublished in the national territory, which address a little of contemporary African cinematographic production, through Sesc Digital platform. Everyone is available throughout the entire festival, except Gagarine Building, online for 24 hours, and you will die at twenty, with a limit of 500 views.

Short “Al-Sit”, by Suzannah Mirghani, is part of the show’s program. Credit: Doha Film Institute/African Film Festival Press Office

Amanda Sousa

Amanda Sousa is a mother, a feminist, is 30 years old and has a degree in Social Communication. Born in São Paulo, currently lives in Jundiaí. She is passionate about music since she understands people. He goes from punk to pop, he likes to discover sounds in all aspects.

We would like to give thanks to the author of this write-up for this incredible material

Concerts, shows and fervo this weekend. check it out now

" ["date_timestamp"]=> int(1635710468) } [9]=> array(11) { ["title"]=> string(76) "Cell-free DNA identifies early signs of relapse in pediatric medulloblastoma" ["link"]=> string(96) "https://bofads.com/cell-free-dna-identifies-early-signs-of-relapse-in-pediatric-medulloblastoma/" ["dc"]=> array(1) { ["creator"]=> string(12) "Tony Grantly" } ["pubdate"]=> string(31) "Sun, 31 Oct 2021 19:22:32 +0000" ["category"]=> string(75) "Health And ScienceCellfreeDNAidentifiesmedulloblastomapediatricrelapsesigns" ["guid"]=> string(26) "https://bofads.com/?p=1227" ["description"]=> string(691) "Journal Reference: Anthony P.Y. Liu, Kyle S. Smith, Rahul Kumar, Leena Paul, Laure Bihannic, Tong Lin, Kendra K. Maass, Kristian W. Pajtler, Murali Chintagumpala, Jack M. Su, Eric Bouffet, Michael J. Fisher, Sridharan Gururangan, Richard Cohn, Tim Hassall, Jordan R. Hansford, Paul Klimo, Frederick A. Boop, Clinton F. Stewart, Julie H. Harreld, Thomas E. Merchant, ... Read more" ["content"]=> array(1) { ["encoded"]=> string(5971) "

Journal Reference:

  1. Anthony P.Y. Liu, Kyle S. Smith, Rahul Kumar, Leena Paul, Laure Bihannic, Tong Lin, Kendra K. Maass, Kristian W. Pajtler, Murali Chintagumpala, Jack M. Su, Eric Bouffet, Michael J. Fisher, Sridharan Gururangan, Richard Cohn, Tim Hassall, Jordan R. Hansford, Paul Klimo, Frederick A. Boop, Clinton F. Stewart, Julie H. Harreld, Thomas E. Merchant, Ruth G. Tatevossian, Geoffrey Neale, Matthew Lear, Jeffery M. Klco, Brent A. Orr, David W. Ellison, Richard J. Gilbertson, Arzu Onar-Thomas, Amar Gajjar, Giles W. Robinson, Paul A. Northcott. Serial assessment of measurable residual disease in medulloblastoma liquid biopsies. Cancer Cell, 2021; DOI: 10.1016/j.ccell.2021.09.012

Medulloblastoma is among the most common malignant pediatric brain tumors. Imaging at the end of therapy is helpful to assess for the absence of bulky disease but, to date, there is no definitive test to declare a patient free of disease. As such, clinicians do not know who is cured or who will relapse but they do know that up to one-third of patients may relapse.

MRD refers to tumor cells that are present during or after cancer treatment has concluded. Detecting these tumor cells, or markers of them, such as cell-free DNA, is vital for recognizing early risk of relapse and potentially heading this off before it has become established.

“We scan patients frequently for the first couple of years when they come off therapy, but unfortunately, by the time we see a recurrence on a scan there is already a lot of disease,” said co-senior author Giles Robinson, M.D., St. Jude Department of Oncology. “Relapsed medulloblastoma harbors an incredibly poor prognosis and for many it is too late to cure. As a result, we sought a better way to determine whether a child is truly clear of disease at the time they come off therapy.

“With this test, we now know that if there is medulloblastoma cell-free DNA in the CSF at the end of therapy, then that patient is very likely to relapse,” Robinson said. “That gives us something we can act on, an opportunity to truly eradicate the disease before it has had a chance to relapse or re-emerge.”

The right test to answer the right question

As part of standard treatment for medulloblastoma, children undergo serial spinal taps to check for disease. This is specific to the treatment of pediatric brain tumors, which are more likely to spread through CSF. Cell-free DNA is not bound by the membrane of a cell and is instead found floating in plasma or CSF. Researchers used CSF samples from patients treated for medulloblastoma on the SJMB03 study to look for cell-free DNA that would indicate the presence of MRD. The trial samples were collected as part of necessary care.

“There’s a lot of interest in the concept of liquid biopsy for cancer, but the technology hadn’t been optimized for pediatric brain tumors,” said corresponding and co-senior author Paul Northcott, Ph.D., St. Jude Department of Developmental Neurobiology. “Through careful scientific trial and error and optimization at the lab bench, we found a protocol that can reliably identify the genomic variations characteristic of medulloblastoma.”

Northcott and his team relied on a methodology called low-coverage whole-genome sequencing that summarizes genome-wide copy number variation (changes in the genetic code). Most medulloblastoma genomes harbor these changes that can be readily detected with this approach.

The results showed that this method of detecting MRD can alert clinicians to the risk of relapse earlier. However, before it can be incorporated into prospective clinical trials, a certified clinical laboratory will need to adopt the test (rather than a research laboratory).

The study’s co-first authors are Anthony Liu, Kyle Smith and Rahul Kumar of St. Jude. The other co-senior author is Amar Gajjar, St. Jude Department of Pediatric Medicine chair. Additional authors are Kendra Maass and Kristian Pajtler of the German Cancer Research Center; Murali Chintagumpala and Jack Su, Texas Children’s Cancer Center; Eric Bouffet, The Hospital for Sick Children; Michael Fisher, Children’s Hospital of Philadelphia; Sridharan Gururangan, UF Health Shands Hospital; Richard Cohn, Sydney Children’s Hospital; Tim Hassall, Queensland Children’s Hospital; Jordan Hansford, The Royal Children’s Hospital; Julie Harreld, Dartmouth Geisel School of Medicine; Richard Gilbertson, Cancer Research UK Cambridge Institute; and Leena Paul, Laure Bihannic, Tong Lin, Paul Klimo Jr., Frederick Boop, Clinton Stewart, Thomas Merchant, Ruth Tatevossian, Geoffrey Neale, Matthew Lear, Jeffery Klco, Brent Orr, David Ellison and Arzu Onar Thomas, all of St. Jude.

The study was funded by the National Cancer Institute (R21CA256386, P30CA021765), the Carson Leslie Foundation Young Investigator Award, the Li Shu Pui Medical Foundation (Training Grant), the Lin Kin Pang-KHU Foundation Scholarship, the Pew-Stewart Scholar for Cancer Research Award, the Sontag Foundation (Distinguished Scientists Award), St. Baldrick’s Foundation (Robert J. Arceci Innovation Award) and ALSAC, the fundraising and awareness organization of St. Jude.

We wish to say thanks to the author of this article for this remarkable content

Cell-free DNA identifies early signs of relapse in pediatric medulloblastoma

" } ["summary"]=> string(691) "Journal Reference: Anthony P.Y. Liu, Kyle S. Smith, Rahul Kumar, Leena Paul, Laure Bihannic, Tong Lin, Kendra K. Maass, Kristian W. Pajtler, Murali Chintagumpala, Jack M. Su, Eric Bouffet, Michael J. Fisher, Sridharan Gururangan, Richard Cohn, Tim Hassall, Jordan R. Hansford, Paul Klimo, Frederick A. Boop, Clinton F. Stewart, Julie H. Harreld, Thomas E. Merchant, ... Read more" ["atom_content"]=> string(5971) "

Journal Reference:

  1. Anthony P.Y. Liu, Kyle S. Smith, Rahul Kumar, Leena Paul, Laure Bihannic, Tong Lin, Kendra K. Maass, Kristian W. Pajtler, Murali Chintagumpala, Jack M. Su, Eric Bouffet, Michael J. Fisher, Sridharan Gururangan, Richard Cohn, Tim Hassall, Jordan R. Hansford, Paul Klimo, Frederick A. Boop, Clinton F. Stewart, Julie H. Harreld, Thomas E. Merchant, Ruth G. Tatevossian, Geoffrey Neale, Matthew Lear, Jeffery M. Klco, Brent A. Orr, David W. Ellison, Richard J. Gilbertson, Arzu Onar-Thomas, Amar Gajjar, Giles W. Robinson, Paul A. Northcott. Serial assessment of measurable residual disease in medulloblastoma liquid biopsies. Cancer Cell, 2021; DOI: 10.1016/j.ccell.2021.09.012

Medulloblastoma is among the most common malignant pediatric brain tumors. Imaging at the end of therapy is helpful to assess for the absence of bulky disease but, to date, there is no definitive test to declare a patient free of disease. As such, clinicians do not know who is cured or who will relapse but they do know that up to one-third of patients may relapse.

MRD refers to tumor cells that are present during or after cancer treatment has concluded. Detecting these tumor cells, or markers of them, such as cell-free DNA, is vital for recognizing early risk of relapse and potentially heading this off before it has become established.

“We scan patients frequently for the first couple of years when they come off therapy, but unfortunately, by the time we see a recurrence on a scan there is already a lot of disease,” said co-senior author Giles Robinson, M.D., St. Jude Department of Oncology. “Relapsed medulloblastoma harbors an incredibly poor prognosis and for many it is too late to cure. As a result, we sought a better way to determine whether a child is truly clear of disease at the time they come off therapy.

“With this test, we now know that if there is medulloblastoma cell-free DNA in the CSF at the end of therapy, then that patient is very likely to relapse,” Robinson said. “That gives us something we can act on, an opportunity to truly eradicate the disease before it has had a chance to relapse or re-emerge.”

The right test to answer the right question

As part of standard treatment for medulloblastoma, children undergo serial spinal taps to check for disease. This is specific to the treatment of pediatric brain tumors, which are more likely to spread through CSF. Cell-free DNA is not bound by the membrane of a cell and is instead found floating in plasma or CSF. Researchers used CSF samples from patients treated for medulloblastoma on the SJMB03 study to look for cell-free DNA that would indicate the presence of MRD. The trial samples were collected as part of necessary care.

“There’s a lot of interest in the concept of liquid biopsy for cancer, but the technology hadn’t been optimized for pediatric brain tumors,” said corresponding and co-senior author Paul Northcott, Ph.D., St. Jude Department of Developmental Neurobiology. “Through careful scientific trial and error and optimization at the lab bench, we found a protocol that can reliably identify the genomic variations characteristic of medulloblastoma.”

Northcott and his team relied on a methodology called low-coverage whole-genome sequencing that summarizes genome-wide copy number variation (changes in the genetic code). Most medulloblastoma genomes harbor these changes that can be readily detected with this approach.

The results showed that this method of detecting MRD can alert clinicians to the risk of relapse earlier. However, before it can be incorporated into prospective clinical trials, a certified clinical laboratory will need to adopt the test (rather than a research laboratory).

The study’s co-first authors are Anthony Liu, Kyle Smith and Rahul Kumar of St. Jude. The other co-senior author is Amar Gajjar, St. Jude Department of Pediatric Medicine chair. Additional authors are Kendra Maass and Kristian Pajtler of the German Cancer Research Center; Murali Chintagumpala and Jack Su, Texas Children’s Cancer Center; Eric Bouffet, The Hospital for Sick Children; Michael Fisher, Children’s Hospital of Philadelphia; Sridharan Gururangan, UF Health Shands Hospital; Richard Cohn, Sydney Children’s Hospital; Tim Hassall, Queensland Children’s Hospital; Jordan Hansford, The Royal Children’s Hospital; Julie Harreld, Dartmouth Geisel School of Medicine; Richard Gilbertson, Cancer Research UK Cambridge Institute; and Leena Paul, Laure Bihannic, Tong Lin, Paul Klimo Jr., Frederick Boop, Clinton Stewart, Thomas Merchant, Ruth Tatevossian, Geoffrey Neale, Matthew Lear, Jeffery Klco, Brent Orr, David Ellison and Arzu Onar Thomas, all of St. Jude.

The study was funded by the National Cancer Institute (R21CA256386, P30CA021765), the Carson Leslie Foundation Young Investigator Award, the Li Shu Pui Medical Foundation (Training Grant), the Lin Kin Pang-KHU Foundation Scholarship, the Pew-Stewart Scholar for Cancer Research Award, the Sontag Foundation (Distinguished Scientists Award), St. Baldrick’s Foundation (Robert J. Arceci Innovation Award) and ALSAC, the fundraising and awareness organization of St. Jude.

We wish to say thanks to the author of this article for this remarkable content

Cell-free DNA identifies early signs of relapse in pediatric medulloblastoma

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